{"id":74561,"date":"2018-03-09T23:19:36","date_gmt":"2018-03-09T23:19:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-inhibidores-de-protea%c2%adna-tirosina-cinasas-en-eosinofilo-humano\/"},"modified":"2018-03-09T23:19:36","modified_gmt":"2018-03-09T23:19:36","slug":"estudio-farmacologico-de-inhibidores-de-protea%c2%adna-tirosina-cinasas-en-eosinofilo-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-inhibidores-de-protea%c2%adna-tirosina-cinasas-en-eosinofilo-humano\/","title":{"rendered":"Estudio farmacol\u00f3gico de inhibidores de prote\u00edna tirosina cinasas en eosin\u00f3filo humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Losa Mar\u00eda Magdalena <\/strong><\/h2>\n<p>La fosforilaci\u00f3n y defosforilaci\u00f3n de prote\u00ednas celulares est\u00e1n implicadas en muchos de los procesos biol\u00f3gicos importantes como el crecimiento o la diferenciaci\u00f3n siendo esencial y regulada en los organismos multicelulares para la comunicaci\u00f3n intercelular. Ptks y ptps mantienen conjuntamente la homeostasis de la fosforilaci\u00f3n en tirosina de prote\u00ednas celulares. en el presente trabajo nos propusimos como objetivo investigar los efectos que tirfostina y genisteina, inhibidores de ptks, y ov y pao, inhibidores de ptps, desarrollaban sobre distintas respuestas celulares proinflamatorias del eosin\u00f3filo humano inducidas por el p\u00e9ptido quimiot\u00e1ctico fmlp. Los resultados de nuestro estudio pusieron de manifiesto la importancia de las ptks y ptps al inhibir respuestas como la liberaci\u00f3n de ros, ecp y epo, s\u00edntesis de ltc4, quimiotaxis o  apoptosis, apuntando la inhibici\u00f3n de las rutas de se\u00f1alizaci\u00f3n que activan las mapks erk1\/2 y p38 como posibles mecanismos de acci\u00f3n para su actividad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacol\u00f3gico de inhibidores de prote\u00edna tirosina cinasas en eosin\u00f3filo humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacol\u00f3gico de inhibidores de prote\u00edna tirosina cinasas en eosin\u00f3filo humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Losa Mar\u00eda Magdalena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Cortijo Gimeno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Morcillo s\u00e1nchez esteban j. <\/li>\n<li>joan albert Barber\u00e1 mir (vocal)<\/li>\n<li>gustavo Juan  samper (vocal)<\/li>\n<li> Peinado cabre victor ivo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Losa Mar\u00eda Magdalena La fosforilaci\u00f3n y defosforilaci\u00f3n de prote\u00ednas celulares est\u00e1n implicadas en muchos de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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