{"id":74605,"date":"2018-03-09T23:19:40","date_gmt":"2018-03-09T23:19:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismo-de-accion-de-los-cannabinoides-en-celulas-tumorales-de-prostata-papel-del-receptor-de-vanilloides-trpv1ao\/"},"modified":"2018-03-09T23:19:40","modified_gmt":"2018-03-09T23:19:40","slug":"mecanismo-de-accion-de-los-cannabinoides-en-celulas-tumorales-de-prostata-papel-del-receptor-de-vanilloides-trpv1ao","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/mecanismo-de-accion-de-los-cannabinoides-en-celulas-tumorales-de-prostata-papel-del-receptor-de-vanilloides-trpv1ao\/","title":{"rendered":"Mecanismo de accion de los cannabinoides en celulas tumorales de prostata papel del receptor de vanilloides trpv1\u00c2\u00ba"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Gracia Sanchez Alonso <\/strong><\/h2>\n<p>Los cannabinoides constituyen un conjunto de compuestos derivados de la planta cannabis sativa. Estos compuestos inducen un aumento significativo de la proliferaci\u00f3n celular en c\u00e9lulas tumorales prost\u00e1ticas.  este efecto se produce a trav\u00e9s de receptores de cannabinoides, cb1 y cb2, mediante la activaci\u00f3n de distintas rutas como la cascada de mapk y la v\u00eda de pi3k\/pkb, tal y como se demuestra en presencia de los antagonistas de los receptores de los receptores, sr1 o antagonista de cb1 y sr2 o antagonista de cb2 y el inhibidor de pi3k, ly 294002. la posible repercusi\u00f3n fisiol\u00f3gica podr\u00eda venir determinada  por el incremento de la secreci\u00f3n del factor de crecimiento nerviosos ngf, expresado tanto en hiperplasia benigna prost\u00e1tica como en cancer de pr\u00f3stata. los cannabinoides tambi\u00e9n inducen un aumento de la expresi\u00f3n del receptor de andr\u00f3genos en c\u00e9lulas dependientes de andr\u00f3genos para su crecimiento, determinando a trav\u00e9s de sus receptores espec\u00edficos, la participaci\u00f3n de este receptor en la regulaci\u00f3n g\u00e9nica encaminada al crecimiento celular.  adem\u00e1s se ha descrito la expresi\u00f3n del receptor de vanilloides tipo i o trpv1 tanto en c\u00e9lulas como en tejido prost\u00e1tico. Estos receptores ionotr\u00f3picos  son canales de cationes no selectivos activados por vanilloides, compuestos derivados del chile o pimiento picante y por cannabinoides, constituyendo otra v\u00eda de se\u00f1alizaci\u00f3n celular, puesto que son capaces de unirse a estos receptores e inducir un incremento de calcio intracelular, lo que determinar\u00eda que este receptor sea funcionalmente activo. Tambi\u00e9n se ha demostrado que trpv1 media parte del efecto proliferativo inducido por cannabinoides.  el hecho de que la transducci\u00f3n de se\u00f1ales sea v\u00eda receptores de cannabinoides o v\u00eda receptores de vanilloides viene determinado por los niveles de expresi\u00f3n de los receptores en el tejido diana y la concentraci\u00f3n local de cannabinoides en ese momento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismo de accion de los cannabinoides en celulas tumorales de prostata papel del receptor de vanilloides trpv1\u00c2\u00ba<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismo de accion de los cannabinoides en celulas tumorales de prostata papel del receptor de vanilloides trpv1\u00c2\u00ba <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Gracia Sanchez Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>laviada Marturet D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Lasunci\u00f3n ripa <\/li>\n<li>Juli\u00e1n Romero paredes (vocal)<\/li>\n<li>Rafael Gutierrez del pozo (vocal)<\/li>\n<li>Juan  Fernando Herrero  gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Gracia Sanchez Alonso Los cannabinoides constituyen un conjunto de compuestos derivados de la planta cannabis sativa. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9399,561,964,347],"tags":[50512,119038,85568,161561,17445,161562],"class_list":["post-74605","post","type-post","status-publish","format-standard","hentry","category-alcala","category-cultivo-celular","category-farmacologia-molecular","category-lipidos","category-oncologia-clinica","tag-juan-fernando-herrero-gonzalez","tag-julian-romero-paredes","tag-laviada-marturet-diaz","tag-maria-gracia-sanchez-alonso","tag-miguel-angel-lasuncion-ripa","tag-rafael-gutierrez-del-pozo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74605"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74605\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}