{"id":74625,"date":"2018-03-09T23:19:40","date_gmt":"2018-03-09T23:19:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-genomico-del-cancer-de-mama-implicaciones-cla%c2%adnicas\/"},"modified":"2018-03-09T23:19:40","modified_gmt":"2018-03-09T23:19:40","slug":"perfil-genomico-del-cancer-de-mama-implicaciones-cla%c2%adnicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/perfil-genomico-del-cancer-de-mama-implicaciones-cla%c2%adnicas\/","title":{"rendered":"\u00abperfil gen\u00f3mico del c\u00e1ncer de mama: implicaciones cl\u00ednicas\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Climent Bataller <\/strong><\/h2>\n<p>A pesar del consenso actual en la elecci\u00f3n de la terapia sist\u00e9mica adjyuvante basada en criterios cl\u00ednicos e histol\u00f3gicos, el 25% de los pacientes con c\u00e1ncer de mama sin afectaci\u00f3n ganglionar (cmgo) presentar\u00e1n reca\u00edda y finalmente morir\u00e1n debido a la enfermedad. Los perfiles de expresi\u00f3n g\u00e9nica de los tumores de c\u00e1ncer de mama representan un predictor potente de la supervivencia, sin embargo, estos sistemas de an\u00e1lisis del genoma humano no se aplican todav\u00eda en la pr\u00e1ctica cl\u00ednica. En esta tesis se examina la posibilidad de genera un predictor gen\u00f3mico del riesgo de reca\u00edda en pacientes con cmgo mediante el an\u00e1lisis del n\u00famero de copias de adn en los genomas tumorales usando arrays gen\u00f3micos.  m\u00e9todos: se han estudiado mediante hibridaci\u00f3n gen\u00f3mica comparada sobre microarrays de adn (array-cgh) un  total de 185 biopsias tumorales obtenidas de pacientes diagnosticadas de cmgo y tratadas en el hospital cl\u00ednico universitario de Valencia. La mediana de seguimiento fue de 82 meses (rango, 11 &#8211; 218). tras la cirug\u00eda, 90 pacientes recibieron quimioterapia adyuvante basada en antracilcinas (grupo ac), mientras que las 95 restantes no recibieron quimoterapia (grupo nt). Para el estudio de las correlaciones entre los datos gen\u00f3micos obtenidos con las caracter\u00edsticas cl\u00ednicas y supervivencia de las pacientes se utiliz\u00f3 el modelo estad\u00edstico de cox. El nivel de significancia de las asociaciones se corrigi\u00f3 mediante los tests m\u00e1s adecuados de ajuste estad\u00edstico para comparaciones m\u00faltiples.  resultados: el an\u00e1lisis de los genomas tumorales de cmgo muestran un perfil gen\u00f3mico caracter\u00edstico basado en ganancia\/amplificaci\u00f3n de las regiones cromos\u00f3micas 1q31-q41, 8q21-q24, 17q12-q21 y 20q12q13, y p\u00e9rdida gen\u00f3mica de 8p21-p23, 11q21-q24, 16q21-q23 y 17p13. La ganacia espec\u00edfica de clones contenidos en las regiones 1q, 16q y la p\u00e9rdida de 16q se asoci\u00f3 con los niveles de expresi\u00f3n de los receptores de estr\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abperfil gen\u00f3mico del c\u00e1ncer de mama: implicaciones cl\u00ednicas\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abperfil gen\u00f3mico del c\u00e1ncer de mama: implicaciones cl\u00ednicas\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Climent Bataller <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 \u00e1ngel Mart\u00ednez Climent<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ben\u00edtez ortiz <\/li>\n<li>dolores Odero Mar\u00eda (vocal)<\/li>\n<li>Miguel Mart\u00edn jim\u00e9nez (vocal)<\/li>\n<li>Jos\u00e9 Palacios calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Climent Bataller A pesar del consenso actual en la elecci\u00f3n de la terapia sist\u00e9mica adjyuvante basada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,212,36483,35,9224,2820],"tags":[161601,7788,161600,120167,50844,42684],"class_list":["post-74625","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-humana","category-biologia-molecular","category-ciencias-de-la-vida","category-citogenetica","category-genetica-humana","tag-dolores-odero-maria","tag-javier-benitez-ortiz","tag-joan-climent-bataller","tag-jose-angel-Martinez-climent","tag-jose-palacios-calvo","tag-miguel-martin-jimenez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74625"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74625\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}