{"id":74630,"date":"2018-03-09T23:19:40","date_gmt":"2018-03-09T23:19:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-genes-de-resistencia-a-antibioticos-y-sus-mecanismos-de-diseminacion-en-cepas-nosocomiales-del-genero-staphylococcus\/"},"modified":"2018-03-09T23:19:40","modified_gmt":"2018-03-09T23:19:40","slug":"caracterizacion-molecular-de-genes-de-resistencia-a-antibioticos-y-sus-mecanismos-de-diseminacion-en-cepas-nosocomiales-del-genero-staphylococcus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bacteriologia\/caracterizacion-molecular-de-genes-de-resistencia-a-antibioticos-y-sus-mecanismos-de-diseminacion-en-cepas-nosocomiales-del-genero-staphylococcus\/","title":{"rendered":"Caracterizaci\u00f3n molecular de genes de resistencia a antibi\u00f3ticos y sus mecanismos de diseminaci\u00f3n en cepas nosocomiales del g\u00e9nero staphylococcus."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leticia Mill\u00e1n Laplana <\/strong><\/h2>\n<p>El objetivo general de este trabajo fue analizar el estado de la epidemiolog\u00eda molecular de los determinantes gen\u00e9ticos de resistencia a antibi\u00f3ticos mls en cepas de staphylococcus aureus y de especies de estafilocococs coagulasa-negativos (scn) aisladas en el servicio de microbiolog\u00eda del hospital cl\u00ednico universitario \u00ablozano blesa\u00bb de zaragoza, as\u00ed como su estructura y regulaci\u00f3n, y completando con el estudio de su diseminaci\u00f3n. As\u00ed mismo, bas\u00e1ndonos en los fenotipos de resistencia a distintos antibi\u00f3ticos, tratar de caracterizar algunos de los genes responsables de estas resistencias y tambi\u00e9n su diseminaci\u00f3n. en las cepas de estafilococos resistentes a eritromicina estudiadas, predomin\u00f3 el fenotipo mlsb constitutivo sobre los fenotipos inducible y ms. Se encontr\u00f3 una alta tasa de cepas multi-resistentes, lo que muestra la eficiente diseminaci\u00f3n de genes de resistencia, siendo mayor en scn que en s. Aureus, lo que sugiere la actuaci\u00f3n de los primeros como reservorio de estos genes. Dicha multi-resistencia no afect\u00f3, sin embargo, a vancomicina y linezolid, que mostraron una excelente actividad in vitro. Se encontr\u00f3 una buena correlaci\u00f3n entre la determinaci\u00f3n de la resistencia a oxacilina mediante diluci\u00f3n en agar y la detecci\u00f3n de meca, observ\u00e1ndose grandes discrepancias con la t\u00e9cnica de difusi\u00f3n con disco, lo que lleva a recomendar la utilizaci\u00f3n de varios m\u00e9todos simult\u00e1neamente para detectar dicha resistencia. el gen erm(c) prevaleci\u00f3 respecto a erm(a) tanto en s. Aureus como en scn, no detect\u00e1ndose mef(a) ni erm(a) subclase erm(tr) en ninguna cepa. Se observ\u00f3 un aumento en la preValencia de erm(b) en cepas cl\u00ednicas de estafilococos, lo que sugiere una propagaci\u00f3n horizontal de este gen desde enterococos, neumococos y\/o estafilococos que compartan nicho ecol\u00f3gico, y una diseminaci\u00f3n clonal de estafilococos portadores del mismo. Se encontraron combinaciones de varios genes erm y de \u00e9stos con msr(a), prevaleciendo este \u00fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de genes de resistencia a antibi\u00f3ticos y sus mecanismos de diseminaci\u00f3n en cepas nosocomiales del g\u00e9nero staphylococcus.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de genes de resistencia a antibi\u00f3ticos y sus mecanismos de diseminaci\u00f3n en cepas nosocomiales del g\u00e9nero staphylococcus. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leticia Mill\u00e1n Laplana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>lus G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castillo Garc\u00eda Francisco javier <\/li>\n<li>carmen Torres manrique (vocal)<\/li>\n<li>estrella Duran sanchez (vocal)<\/li>\n<li>fernanda Ruiz larrea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leticia Mill\u00e1n Laplana El objetivo general de este trabajo fue analizar el estado de la epidemiolog\u00eda molecular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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