{"id":74646,"date":"2018-03-09T23:19:45","date_gmt":"2018-03-09T23:19:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/participacion-del-sistema-cannabinoide-endogeno-en-los-fenomenos-de-adiccion-interaccion-con-otros-sistemas-de-neurotransmision\/"},"modified":"2018-03-09T23:19:45","modified_gmt":"2018-03-09T23:19:45","slug":"participacion-del-sistema-cannabinoide-endogeno-en-los-fenomenos-de-adiccion-interaccion-con-otros-sistemas-de-neurotransmision","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psicologia\/participacion-del-sistema-cannabinoide-endogeno-en-los-fenomenos-de-adiccion-interaccion-con-otros-sistemas-de-neurotransmision\/","title":{"rendered":"Participaci\u00f3n del sistema cannabinoide end\u00f3geno en los fen\u00f3menos de adicci\u00f3n. interacci\u00f3n con otros sistemas de neurotransmisi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Casta\u00f1\u00e9 Forn <\/strong><\/h2>\n<p>Con la finalidad de explorar con profundidad las bases neurobiol\u00f3gicas de la adicci\u00f3n a cannabinoides hemos llevado a cabo diferentes estudios farmacol\u00f3gicos y moleculares. El sustrato neuroanat\u00f3mico de la dependencia f\u00edsica de cannabinoides ha sido investigado en ratones que recibieron un tratamiento cr\u00f3nico con el agonista win55,212-2. En este estudio, se observ\u00f3 que el cerebelo y en menor grado el hipocampo y la am\u00edgdala, participan en la manifestaci\u00f3n comportamental del s\u00edndrome de abstinencia de cannabinoides. estas tres \u00e1reas se caracterizan por presentar una alta densidad de receptores cannabinoides cb1. Adem\u00e1s, hemos evaluado la participaci\u00f3n de diversos sistemas de neurotransmisi\u00f3n como son los sistemas opioide y purin\u00e9rgico end\u00f3genos, en las respuestas comportamentales inducidas tras la administraci\u00f3n de cannabinoides. Especialmente, nos hemos interesado por aquellas respuestas que est\u00e1n estrechamente relacionadas con las propiedades adictivas de dichos compuestos, como son los efectos reforzantes y aversivos y el desarrollo de dependencia f\u00edsica. Para ello hemos utilizado ratones modificados gen\u00e9ticamente. el sistema opioide end\u00f3geno ha sido relacionado con la manifestaci\u00f3n de las propiedades adictivas de los cannabinoides. En este trabajo, mediante la utilizaci\u00f3n de ratones dobles mutantes mor\/dor, hemos demostrado que se requiere una acci\u00f3n cooperativa entre ambos tipos de receptores opioides para que el s\u00edndrome de abstinencia cannabinoide se exprese enteramente. por otro lado, los ratones con una supresi\u00f3n del gen que codifica para el receptor de adenosina a2a no mostraron ni preferencia de plaza ni aversi\u00f3n de plaza condicionadas a la administraci\u00f3n de thc. Adem\u00e1s, estos ratones presentaron un s\u00edndrome de abstinencia de thc de menor severidad, lo que sugiere una participaci\u00f3n espec\u00edfica de los receptores a2a en efectos de los cannabinoides relacionados con sus propiedades adictivas. Finalmente,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participaci\u00f3n del sistema cannabinoide end\u00f3geno en los fen\u00f3menos de adicci\u00f3n. interacci\u00f3n con otros sistemas de neurotransmisi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participaci\u00f3n del sistema cannabinoide end\u00f3geno en los fen\u00f3menos de adicci\u00f3n. interacci\u00f3n con otros sistemas de neurotransmisi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Casta\u00f1\u00e9 Forn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Olga Valverde Granados<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Pazos carro <\/li>\n<li>Emilio Ambrosio flores (vocal)<\/li>\n<li>Javier Fernandez ruiz (vocal)<\/li>\n<li>Carlos Manuel Gonz\u00e1lez arag\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Casta\u00f1\u00e9 Forn Con la finalidad de explorar con profundidad las bases neurobiol\u00f3gicas de la adicci\u00f3n a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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