{"id":74669,"date":"2018-03-09T23:19:45","date_gmt":"2018-03-09T23:19:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-por-la-poli-adp-ribosa-polimerasa-1-de-la-expresion-genica-durante-la-carcinigenesis-epidermica\/"},"modified":"2018-03-09T23:19:45","modified_gmt":"2018-03-09T23:19:45","slug":"modulacion-por-la-poli-adp-ribosa-polimerasa-1-de-la-expresion-genica-durante-la-carcinigenesis-epidermica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-por-la-poli-adp-ribosa-polimerasa-1-de-la-expresion-genica-durante-la-carcinigenesis-epidermica\/","title":{"rendered":"Modulaci\u00f3n por la poli-adp-ribosa polimerasa-1 de la expresi\u00f3n g\u00e9nica durante la carcinig\u00e9nesis epid\u00e9rmica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco David Mart\u00edn Oliva <\/strong><\/h2>\n<p>La p\u00e9rdida de funci\u00f3n de la prote\u00edna nuclear parp-1 (poli(adp)ribosa plimerasa-1)interfiere en el proceso de carcinog\u00e9nesis qu\u00edmica, retrasando el crecimiento tumoral. esto seha puesto de manifiesto mediante el uso de ratones gen\u00e9ticamente deficientes en parp-1. Estos ratones son menos susceptibles a la aparici\u00f3n y desarrollo de tumores de piel tras tratamiento de cuarcinog\u00e9nesis qu\u00edmica epitelial. Esto es debido, en gran parte, en que en ausencia de parp-1 hay una deficiencia en la activaci\u00f3n de los factores de transcripci\u00f3n nfkb y ap-1 y , por tanto, no pueden ser expresados los genes bajo su control, necesarios para el crecimiento tumoral. El uso de un inhibidor farmacol\u00f3gico de la actividad enzim\u00e1tica de parp-1, ocasiona tambi\u00e9n un retraso temporal en la aparici\u00f3n de tumores, una disminuci\u00f3n del n\u00famero de tumores desarrollados y de su tama\u00f1o medio. Los ensayos de expresi\u00f3n g\u00e9nica han puesto de manifiesto que durante la promoci\u00f3n tumoral las pieles de los ratones parentales, muestran inducci\u00f3n en un importante n\u00famero de gense asociados con patolog\u00edas tumorales, procesos de estr\u00e9s oxidativo, respuesta inmune, inflamaci\u00f3n y arigiog\u00e9nesis que no se corresponden con lo que se observa en ratones con ausencia de parp-1 o tratados con el inhibidor de parp. Esto se debe en parte a que la inhivbici\u00f3n o delecci\u00f3n gen\u00e9tica de parp-1 est\u00e1 asociada a cambios en la expresi\u00f3n g\u00e9nica relacionadas con el desarrollo tumoral. por tanto, la inhibici\u00f3n dela actividad enzim\u00e1tica de parp-1 puede ser de gran utilidad en el dise\u00f1o de nuevas terapias anti-neopl\u00e1sicas tanto por su capacidad de prevenir procesos de reparaci\u00f3n del adn durante el tratamiento cl\u00e1sico con quimioterapia y\/o irradiaci\u00f3n, como por representar una efectiva terapia para bloquear la expresi\u00f3n de genes clave en el proceso de pormoci\u00f3n\/progresi\u00f3n tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n por la poli-adp-ribosa polimerasa-1 de la expresi\u00f3n g\u00e9nica durante la carcinig\u00e9nesis epid\u00e9rmica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n por la poli-adp-ribosa polimerasa-1 de la expresi\u00f3n g\u00e9nica durante la carcinig\u00e9nesis epid\u00e9rmica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco David Mart\u00edn Oliva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Oliver Pozo Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raimundo Garc\u00eda delmoral garrido <\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<li>Jos\u00e9 Yelamos lopez (vocal)<\/li>\n<li>abelardo L\u00f3pez rivas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco David Mart\u00edn Oliva La p\u00e9rdida de funci\u00f3n de la prote\u00edna nuclear parp-1 (poli(adp)ribosa plimerasa-1)interfiere en el 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