{"id":7474,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-eficacia-y-toxicidad-de-nuevos-farmacos-en-un-modelo-experimental-refinado-de-vitreorretinopatia-proliferativa\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-eficacia-y-toxicidad-de-nuevos-farmacos-en-un-modelo-experimental-refinado-de-vitreorretinopatia-proliferativa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-eficacia-y-toxicidad-de-nuevos-farmacos-en-un-modelo-experimental-refinado-de-vitreorretinopatia-proliferativa\/","title":{"rendered":"Estudio de eficacia y toxicidad de nuevos farmacos en un modelo experimental refinado de vitreorretinopatia proliferativa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Cano Parra <\/strong><\/h2>\n<p>Material y metodos: en la presente tesis doctoral vamos a realizar un estudio in vitro sobre el epr humano valorando dos parametros: 1) inhibicion de crecimiento:  expusimos los cultivos de baja densidad (3.000 celulas) a concentraciones crecientes de mitomicina-c y 5-fluoracilo. 2) citotoxicidad: se realizo una exposicion unica a diferentes concentraciones de los farmacos sobre un cultivo confluente de 10.000 celulas. Realizamos tambien un estudio de eficacia in vivo: un total de 60 conejos pigmentados, de peso entre 1.5 y 2.5 kg siguieron el modelo refinado de vpr segun la tecnica de compresion vitrea mediada por gas descrita por chandler. Los conejos fueron randomizados en 4 grupos, se inyectaron a nivel intravitreo en cada grupo, en condiciones esteriles las siguientes soluciones: grupo control (n=14): 0.1 ml de pbs y grupo tratado con mitomicina-c (n=14): inyectamos 0.1 ml de mitomicina-c a una concentracion 0.02 mg\/ml.  grupo control liposomas (n=16): inyectamos 0.1 ml. De liposomas vacios que contenian solamente sucrosa. Grupo tratado liposomas 5-fur (n=16): inyectamos 0.1 ml de liposomas multivesiculares conteniendo 5-fluororidina a una concentracion de 0.1 mg\/0.1 ml. Se clasificaban los ojos en estadios de vpr en cada punto de la observacion siguiendo los estadios de hida valorando el exito o fracaso de la mitomicina-c y de los liposomas de 5-fur en funcion de la ausencia del drt (estadios 0-4) o presencia del mismo (estadios 5-7). Se valoro en conejos tambien para ambos farmacos la toxicidad retiniana (n=18) a microscopia optica y electronica, asi como la toxicidad endotelial (n=24) de la dosis intravitrea utilizada. Se correlacionaron las membranas experimentales con las humanas. Resultados: 1-a identica concentracion, la mitomicina-c es mas eficaz que el 5-fluoracilo en su capacidad de inhibir in vitro el crecimiento de las celulas del epitelio pigmentario de la retina humana.  2-la inyeccion intravitrea de mitomicin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de eficacia y toxicidad de nuevos farmacos en un modelo experimental refinado de vitreorretinopatia proliferativa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de eficacia y toxicidad de nuevos farmacos en un modelo experimental refinado de vitreorretinopatia proliferativa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Cano Parra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel D\u00edaz Llopis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonia Fons Moreno <\/li>\n<li>M\u00aa Amparo Navea Tejerina (vocal)<\/li>\n<li> Onrubia Fuertes Juan  Electo (vocal)<\/li>\n<li>Fernando Soler Fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Cano Parra Material y metodos: en la presente tesis doctoral vamos a realizar un estudio in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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