{"id":74745,"date":"2018-03-09T23:19:49","date_gmt":"2018-03-09T23:19:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-herramientas-para-evaluar-y-superar-la-resistencia-a-la-quimioterapia-antitumoral-mediada-por-proteinas-abc\/"},"modified":"2018-03-09T23:19:49","modified_gmt":"2018-03-09T23:19:49","slug":"desarrollo-de-herramientas-para-evaluar-y-superar-la-resistencia-a-la-quimioterapia-antitumoral-mediada-por-proteinas-abc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-herramientas-para-evaluar-y-superar-la-resistencia-a-la-quimioterapia-antitumoral-mediada-por-proteinas-abc\/","title":{"rendered":"Desarrollo de herramientas para evaluar y superar la resistencia a la quimioterapia antitumoral mediada por proteinas abc."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Vallejo Barron <\/strong><\/h2>\n<p>Durante el transcurso de esta tesis doctoral se han desarrollado distintas herramientas experimentales de utilidad para conocer con mayor profundidad los mecanismos de resistencia a la quimioterapia antitumoral mediada por prote\u00ednas abc. La puesta a punto de modelos experimentales moleculares como la expresi\u00f3n de prote\u00ednas abc en oocitos de xenopus laevis; el desarrollo de l\u00edneas celulares resistentes al tratamiento con distintos antineopl\u00e1sicos; la vectorizaci\u00f3n de compuestos con actividad farmacol\u00f3gica antitumoral mediante su uni\u00f3n a \u00e1cidos biliares; o la vehiculizaci\u00f3n de estos compuestos a trav\u00e9s de medios f\u00edsicos, como son los liposomas, se han mostrado herramientas \u00fatiles para el desarrollo de estrategias encaminadas a superar la resistencia antitumoral. El c\u00e1ncer es una de las enfermedades de mayor incidencia y peor pron\u00f3stico a nivel mundial en nuestros d\u00edas. Por ello, uno de los objetivos prioritarios de la investigaci\u00f3n biom\u00e9dica actual es el desarrollo de tratamientos eficaces contra \u00e9l.  dentro de los inconvenientes asociados a la quimioterapia, presenta especial relevancia la resistencia que las c\u00e9lulas tumorales desarrollan frente al tratamiento farmacol\u00f3gico. Uno de los mecanismos de resistencia a la quimioterapia m\u00e1s importante es la sobreexpresi\u00f3n de prote\u00ednas abc (\u00abatp-binding cassette\u00bb) (lage, 2003), prote\u00ednas de membrana capaces de expulsar una gran variedad de compuestos al exterior celular a expensas de la hidr\u00f3lisis  una de las conclusiones m\u00e1s relevantes de este trabajo es que la resistencia tumoral debida fundamentalmente a la sobreexpresi\u00f3n de prote\u00ednas abc puede superarse por combinaci\u00f3n de dos estrategias de vectorizaci\u00f3n: la uni\u00f3n del agente citost\u00e1tico a un \u00e1cido biliar y la vehicularizaci\u00f3n de la mol\u00e9cula resultante en liposomas cati\u00f3nicos, lo que consigue una mayor acumulaci\u00f3n del f\u00e1rmaco en el tejido tumoral y disminuye los posibles efectos adversos debidos a la toxic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de herramientas para evaluar y superar la resistencia a la quimioterapia antitumoral mediada por proteinas abc.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de herramientas para evaluar y superar la resistencia a la quimioterapia antitumoral mediada por proteinas abc. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Vallejo Barron <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Reglero chillon <\/li>\n<li>edith Broth-laroche (vocal)<\/li>\n<li> Martin calvo M\u00aa Luisa (vocal)<\/li>\n<li>Mar\u00eda  teresa Miras portugal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Vallejo Barron Durante el transcurso de esta tesis doctoral se han desarrollado distintas herramientas experimentales de 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