{"id":74763,"date":"2018-03-09T23:19:52","date_gmt":"2018-03-09T23:19:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-6cd17p-rpl33a-en-la-biogenesis-de-ribosomas-y-en-el-inicio-de-la-traduccion\/"},"modified":"2018-03-09T23:19:52","modified_gmt":"2018-03-09T23:19:52","slug":"funcion-de-6cd17p-rpl33a-en-la-biogenesis-de-ribosomas-y-en-el-inicio-de-la-traduccion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/funcion-de-6cd17p-rpl33a-en-la-biogenesis-de-ribosomas-y-en-el-inicio-de-la-traduccion\/","title":{"rendered":"Funcion de 6cd17p (rpl33a) en la biogenesis de ribosomas y en el inicio de la traduccion"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martin Marcos Mar\u00eda  Del Pilar <\/strong><\/h2>\n<p>Gcn4p es un activador transcripcional de al menos 539 genes en saccharomyces cerevisiae. La expresi\u00f3n del gen gcn4 est\u00e1 regulada traduccionalmente en funci\u00f3n de la disponibilidad de amino\u00e1cidos, por un mecanismo de \u00abreiniciaci\u00f3n de la traducci\u00f3n\u00bb que depende de cuatro  fases de lectura cortas en la regi\u00f3n l\u00edder del mrna-gcn4 y por una serie de efectores positivos (gcn) y negativos (gcd).  la caracterizaci\u00f3n gen\u00e9tica de un mutante espont\u00e1neo gcd17 ha permitido identificar a rpl33a como un nuevo gen gcd, cuyo producto se requiere para la represi\u00f3n traduccional de gcn4 en s. Cerevisiae. L33a es una prote\u00edna ribos\u00f3mica esencial de la subunidad 60s que forma parte de una familia muy conservada de prote\u00ednas eucari\u00f3ticas implicadas en uni\u00f3n a trnas.  la mutaci\u00f3n puntual rpl33a-1 determina la sustituci\u00f3n de la glicina en posici\u00f3n 76 por una arginina, en un dominio de la prote\u00edna l33a muy conservado evolutivamente. Un modelo de la estructura tridimensional de l33a predice que la g76 forma parte de un lazo externo r\u00edgido, y que la mutaci\u00f3n no alterar\u00eda el plegamiento global de la prote\u00edna. Mutaciones sint\u00e9ticas que reemplazan ciertos residuos del mismo dominio por otros b\u00e1sicos tienen las mismas consecuencias fenot\u00edpicas que la mutaci\u00f3n espont\u00e1nea rpl33a-1.  tanto la mutaci\u00f3n rpl33a-1 como la sustituci\u00f3n de rpl33a por un alelo nulo, provocan m\u00faltiples defectos en el procesamiento de los rnas ribos\u00f3micos y en el ensamblaje de las pre-part\u00edculas 60s, causando un grave d\u00e9ficit de subunidades 60s maduras en la c\u00e9lula.  la carencia de subunidades 60s origina graves defectos en el inicio de la traducci\u00f3n general de mrnas en la levadura, pero favorece la traducci\u00f3n del mrna-gcn4 en particular. El mecanismo por el que ocurre este fen\u00f3meno en mutantes gcd17 se ha tratado de interpretar proponiendo varios modelos, basados en el de regulaci\u00f3n traduccional de gcn4 e integrando los datos obtenidos en este trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion de 6cd17p (rpl33a) en la biogenesis de ribosomas y en el inicio de la traduccion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion de 6cd17p (rpl33a) en la biogenesis de ribosomas y en el inicio de la traduccion <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martin Marcos Mar\u00eda  Del Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Tamame Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  pedro Garc\u00eda ballesta <\/li>\n<li>Jes\u00fas De la cruz diaz (vocal)<\/li>\n<li>Andr\u00e9s Aguilera l\u00f3pez (vocal)<\/li>\n<li>mercedes Dosil castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martin Marcos Mar\u00eda Del Pilar Gcn4p es un activador transcripcional de al menos 539 genes en saccharomyces [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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