{"id":74800,"date":"2018-03-09T23:19:52","date_gmt":"2018-03-09T23:19:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucions-al-disseny-sa%c2%adntesi-i-aplicacions-de-quimioteques-combinata%c2%b2ries-de-peptoides\/"},"modified":"2018-03-09T23:19:52","modified_gmt":"2018-03-09T23:19:52","slug":"contribucions-al-disseny-sa%c2%adntesi-i-aplicacions-de-quimioteques-combinata%c2%b2ries-de-peptoides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/contribucions-al-disseny-sa%c2%adntesi-i-aplicacions-de-quimioteques-combinata%c2%b2ries-de-peptoides\/","title":{"rendered":"Contribucions al disseny, s\u00edntesi i aplicacions de quimioteques combinat\u00f3ries de peptoides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Cort\u00e9s Barea <\/strong><\/h2>\n<p>El inter\u00e9s principal de la tesis se centra en la utilizaci\u00f3n de las t\u00e9cnicas combinatorias para dise\u00f1ar y sintetizar una quimioteca de peptoides. Los peptoides son un tipo de peptidomim\u00e9ticos cuya estructura general est\u00e1 basada en un esqueleto de glicinas n-sustitu\u00eddas. Su estructura es muy apropiada para poder aplicar la estrategia combinatoria del rastreo posicional para su s\u00edntesis en fase s\u00f3lida. Estos compuestos tienen una gran inter\u00e9s en el \u00e1rea biom\u00e9dica. As\u00ed pues, el cribado de la quimioteca de peptoides frente a diferentes dianas biol\u00f3gicas de inter\u00e9s terap\u00e9utico ha llevado a la identificaci\u00f3n de dos potentes neutrilizadores del fenotipo de mdr en el \u00e1rea del c\u00e1ncer, as\u00ed como de dos potentes inhibidores de lps en el \u00e1rea del shock s\u00e9ptico. Estos compuestos han representado un punto de partida para la optimizaci\u00f3n de sus estructuras para dise\u00f1ar nuevos compuestos que presenten mayor actividad y selectividad frente a sus dianas.  por otra parte, se ha llevado a cabo la optimizaci\u00f3n de un proceso para obtener peptoides con un extremo carbox\u00edlico terminal (peptoides \u00e1cidos) con el objetivo de poder acoplar este tipo de compuestos a soportes s\u00f3lidos tales como columnas de se farosa o agarosa, as\u00ed como para poder biotinilizarlos y acoplarlos a columnas de agarosa con adivina. Con este tipo de columnas con el peptoide inmobilziado se ha utilizado la t\u00e9cnica de la cromatograf\u00eda de afinidad para identificar las dianas potenciales de un peptoide de un extracto proteico que conten\u00eda prote\u00ednas de diferentes naturaleza.  el estudio para obtener peptoides \u00e1cidos ha conllevado al planteamiento de dos nuevas quimiotecas basadas en una estructura general de peptoides d\u00edmeros y de peptoides d\u00edmeros-c\u00edclicos, que se realizar\u00e1 en un futuro pr\u00f3ximo en nuestro de investigaci\u00f3n. Este tipo de mol\u00e9culas pueden ser muy interesantes en estudios de interacci\u00f3n prote\u00edna-prote\u00edna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucions al disseny, s\u00edntesi i aplicacions de quimioteques combinat\u00f3ries de peptoides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucions al disseny, s\u00edntesi i aplicacions de quimioteques combinat\u00f3ries de peptoides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Cort\u00e9s Barea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Messeguer Peypoch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier De mendoza sans <\/li>\n<li>rodolfo Lavilla grifols (vocal)<\/li>\n<li>jordi Teixid\u00f3 closa (vocal)<\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Cort\u00e9s Barea El inter\u00e9s principal de la tesis se centra en la utilizaci\u00f3n de las t\u00e9cnicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,17,416],"tags":[18986,34359,15013,89956,161905,85585],"class_list":["post-74800","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-quimica","category-quimica-organica","tag-angel-messeguer-peypoch","tag-enrique-perez-paya","tag-javier-de-mendoza-sans","tag-jordi-teixido-closa","tag-nuria-cortes-barea","tag-rodolfo-lavilla-grifols"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74800"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74800\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}