{"id":74813,"date":"2018-03-09T23:19:52","date_gmt":"2018-03-09T23:19:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neurotransmision-intraseptal-efecto-del-peptido-b-amiloide-25-35\/"},"modified":"2018-03-09T23:19:52","modified_gmt":"2018-03-09T23:19:52","slug":"neurotransmision-intraseptal-efecto-del-peptido-b-amiloide-25-35","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/neurotransmision-intraseptal-efecto-del-peptido-b-amiloide-25-35\/","title":{"rendered":"Neurotransmision intraseptal: efecto del peptido b-amiloide (25-35)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julio Santos Torres <\/strong><\/h2>\n<p>El septum medial se interconecta con el hipocampo a trav\u00e9s de neuronas colin\u00e9rgicas, glutamat\u00e9rgicas y gaba\u00e9rgicas regulando los procesos de aprendizaje y memoria, y generaci\u00f3n de ritmos. En el presente trabajo se realizaron registros in vitro de neuronas del \u00e1rea septal medial de ratas, mediante las t\u00e9cnicas de fijaci\u00f3n de corriente (current clamp) y de fijaci\u00f3n de voltaje (voltage \/ patch clamp). Se caracterizaron las c\u00e9lulas, se determinaron tipos de receptores que median y modulan la respuesta sin\u00e1ptica, mediante el uso de agonistas y antagonistas espec\u00edficos. Se estudi\u00f3 el efecto del p\u00e9ptido  -amiloide(25-35), principal componente de las placas seniles en la enfermedad de alzheimer, sobre la neurotransmisi\u00f3n excitatoria intraseptal, y sobre la generaci\u00f3n de potenciales de acci\u00f3n. Se analiz\u00f3 tambi\u00e9n la plasticidad sin\u00e1ptica a corto plazo y se inyecto biocitina para observar la morfolog\u00eda de la neurona registrada.  se caracterizaron neuronas de descarga lenta, de descarga regular, de descarga tipo burst y de descarga r\u00e1pida. Se observaron potenciales excitatorios postsin\u00e1pticos  (peps) mediados por glutamato y modulados por acetilcolina y por gaba. Durante la perfusi\u00f3n con  -amiloide las respuestas excitatorias fueron deprimidas en el 70% de los casos, siendo este efecto irreversible en la mayor\u00eda de los casos, sin detectarse cambios en la generaci\u00f3n de potenciales de acci\u00f3n. \u00e9ste efecto depresor no fue impedido ni revertido por nicotina, mientras que en muchos casos fue impedido por atropina y pirenzepina sugiriendo la implicaci\u00f3n de receptores colin\u00e9rgicos muscar\u00ednicos. se sugiere que estos estudios pueden ayudar a revelar los procesos que median la acci\u00f3n sin\u00e1ptica del  -amiloide y a explicar las alteraciones cognitivas durante el desarrollo de la enfermedad de alzheimer antes de la aparici\u00f3n de marcadores histopatol\u00f3gicos como las placas seniles y ovillos neurofibrilares, as\u00ed como estudiar neuropr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neurotransmision intraseptal: efecto del peptido b-amiloide (25-35)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neurotransmision intraseptal: efecto del peptido b-amiloide (25-35) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julio Santos Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Yajeya P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Delgado Garc\u00eda <\/li>\n<li>Andr\u00e9s Morales calderon (vocal)<\/li>\n<li>margarita Heredia chons (vocal)<\/li>\n<li>pilar G\u00f3mez ramos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julio Santos Torres El septum medial se interconecta con el hipocampo a trav\u00e9s de neuronas colin\u00e9rgicas, glutamat\u00e9rgicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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