{"id":74826,"date":"2018-03-09T23:19:56","date_gmt":"2018-03-09T23:19:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-actividad-citotoxica-de-la-proteasa-del-virus-de-la-inmunodeficiencia-humana-tipo-1\/"},"modified":"2018-03-09T23:19:56","modified_gmt":"2018-03-09T23:19:56","slug":"caracterizacion-de-la-actividad-citotoxica-de-la-proteasa-del-virus-de-la-inmunodeficiencia-humana-tipo-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-de-la-actividad-citotoxica-de-la-proteasa-del-virus-de-la-inmunodeficiencia-humana-tipo-1\/","title":{"rendered":"Caracterizacion de la actividad citotoxica de la proteasa del virus de la inmunodeficiencia humana tipo 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Blanco Fuentes <\/strong><\/h2>\n<p>La actividad de la proteasa (hiv-1pr) es fundamental en el ciclo replicativo del virus de la inmunodeficiencia humana (hiv). Su funci\u00f3n es el procesamiento de las poliprote\u00ednas virales para la generar part\u00edculas estructuralmente maduras y con capacidad infectiva. En este trabajo se describe que hiv-1pr podr\u00eda participar, adem\u00e1s, en la muerte celular de c\u00e9lulas infectadas con hiv-1. Hiv-1pr se expres\u00f3 en la levadura saccharomyces cerevisiae asi como en c\u00e9lulas de mam\u00edfero. En ambos casos la expresi\u00f3n de la proteasa fue t\u00f3xica para las c\u00e9lulas ya que indujo alteraciones en la permeabilidad de la membrana plasm\u00e1tica seguidas de lisis celular. adem\u00e1s, las alteraciones morfol\u00f3gicas causadas por hiv-1pr fueron muy similares en ambos tipos celulares. En el caso de las c\u00e9lulas de mam\u00edfero hiv-1pr fue t\u00f3xica tanto utilizando un sistema de sobre-expresi\u00f3n como expres\u00e1ndola a niveles m\u00e1s fisiol\u00f3gicos a partir de una poliprote\u00edna. En este trabajo se describe, adem\u00e1s, un sistema en levaduras para analizar la capacidad inhibitoria de distintos compuestos sobre hiv-1pr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de la actividad citotoxica de la proteasa del virus de la inmunodeficiencia humana tipo 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de la actividad citotoxica de la proteasa del virus de la inmunodeficiencia humana tipo 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Blanco Fuentes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carrasco Llamas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ortin monton <\/li>\n<li>m. angeles Mu\u00f1oz fernandez (vocal)<\/li>\n<li>Antonio Alcami pertejo (vocal)<\/li>\n<li>Rafael Blasco lozano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Blanco Fuentes La actividad de la proteasa (hiv-1pr) es fundamental en el ciclo replicativo del virus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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