{"id":74859,"date":"2018-03-09T23:19:56","date_gmt":"2018-03-09T23:19:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-sistema-renina-angiotensina-glomerular-en-el-desarrollo-de-la-nefropata%c2%ada-diabetica-en-un-modelo-experimental-de-diabetes-inducida-por-estreptozotocina-en-ratas\/"},"modified":"2018-03-09T23:19:56","modified_gmt":"2018-03-09T23:19:56","slug":"papel-del-sistema-renina-angiotensina-glomerular-en-el-desarrollo-de-la-nefropata%c2%ada-diabetica-en-un-modelo-experimental-de-diabetes-inducida-por-estreptozotocina-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-sistema-renina-angiotensina-glomerular-en-el-desarrollo-de-la-nefropata%c2%ada-diabetica-en-un-modelo-experimental-de-diabetes-inducida-por-estreptozotocina-en-ratas\/","title":{"rendered":"Papel del sistema renina angiotensina glomerular en el desarrollo de  la nefropat\u00edadiab\u00e9tica en un modelo experimental de diabetes inducida por estreptozotocina en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Vieitez Garc\u00eda <\/strong><\/h2>\n<p>La nefropat\u00eda diab\u00e9tica es la causa m\u00e1s com\u00fan de complicaciones microvasculares en pacientes con diabetes mellitus tipo 1. El presente trabajo se centr\u00f3 en el estudio de los cambios glomerulares observados tras el bloqueo sist\u00e9mico y glomerular del sistema renina angiotensina (sra) en diabetees. Tambi\u00e9n se estudiaron las interrelaciones entre el tnf-alfa y el resto de factores de crecimiento y citoquinas, as\u00ed como su implicaci\u00f3n en las lesiones renales asociadas a la diabetes.  a ratas spague-dawley se les administr\u00f3 intraperitonealmente estreptoxotocina, y se consideraron diab\u00e9ticas cuando la glucemia fue superior a 300 mg\/dl. para mantener el peso corporal y lograr una supervivencia prolongada, se les inyect\u00f3 insulina diariamente que dur\u00f3 el experimento, manteniendo una glucemia superior a 300 mg\/dl. A partir de la primera semana, cada animal recibi\u00f3 el tratamiento correspondiente seg\u00fan el grupo experimental al que correspondiera:  experimento 1  20 animales diab\u00e9ticos y uninefrectomizados se dividieron en 2 grupos id n=10, que recibi\u00f3 irbesart\u00e1n (50mg\/kg) por c\u00e1nula diariamente, grupo control diab\u00e9tico (cd) n=10 que recibi\u00f3 veh\u00edculo, y se emple\u00f3 otro grupo de ratas no diab\u00e9ticas uninefrectomizadas (nd). Tras 8 meses de tratamiento se determin\u00f3 el efecto de este f\u00e1rmaco sobre la funci\u00f3n renal, expresi\u00f3n glomerular de los receptores de angiotensina at1 y at2, angiotensinaii, tgf-beta, pdgf-b, tnf-alfa y vegf.  experimento 2  20 animales diab\u00e9ticos de 4 meses de evoluci\u00f3n fueron sacrificados para extraer los ri\u00f1ones y aislar los glom\u00e9rulos. Estos se incubaron durante 24 horas con dosis crecientes de irbesart\u00e1n (0, 0,01, 0,1 y 1 umol\/l).  posteriormente se determin\u00f3 la expresi\u00f3n glomerular de los receptores de angiotensina at1, y at2, angitensinaii, tgf-beta, pdgf-b, tnf-alfa y vegf.  experimento 3  20 animales diab\u00e9ticos y uninefrectomizados tras 8 meses se dividieron en 2 grupos: grupo ed n=1<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del sistema renina angiotensina glomerular en el desarrollo de  la nefropat\u00edadiab\u00e9tica en un modelo experimental de diabetes inducida por estreptozotocina en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del sistema renina angiotensina glomerular en el desarrollo de  la nefropat\u00edadiab\u00e9tica en un modelo experimental de diabetes inducida por estreptozotocina en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Vieitez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar G\u00f3mez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Del castillo garcia <\/li>\n<li>rosa Mar\u00eda Tol\u00f3n rafael (vocal)<\/li>\n<li>mercedes Rebuelta lizabe (vocal)<\/li>\n<li>Jos\u00e9 Balsa barro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Vieitez Garc\u00eda La nefropat\u00eda diab\u00e9tica es la causa m\u00e1s com\u00fan de complicaciones microvasculares en pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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