{"id":74972,"date":"2018-03-09T23:20:04","date_gmt":"2018-03-09T23:20:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/requerimientos-del-peptido-de-fusion-para-la-funcionalidad-de-la-protea%c2%adna-f-del-virus-respiratorio-sincitial-humano-vrsh\/"},"modified":"2018-03-09T23:20:04","modified_gmt":"2018-03-09T23:20:04","slug":"requerimientos-del-peptido-de-fusion-para-la-funcionalidad-de-la-protea%c2%adna-f-del-virus-respiratorio-sincitial-humano-vrsh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/requerimientos-del-peptido-de-fusion-para-la-funcionalidad-de-la-protea%c2%adna-f-del-virus-respiratorio-sincitial-humano-vrsh\/","title":{"rendered":"Requerimientos del p\u00e9ptido de fusi\u00f3n para la funcionalidad de la prote\u00edna f del virus respiratorio sincitial humano vrsh"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diana Mart\u00edn Lorenzo <\/strong><\/h2>\n<p>El virus respiratorio sincitial humano (vrsh)es el principal agente causante de infecciones graves del tracto respiratorio inferior en ni\u00f1os de corta edad, en adultos inmunodeprimidos y en ancianos, produciendo bronquiolitis y neumonias. El vrshpertenece a la familia paramyxoviridae y al g\u00e9nero pneumovirus. El genoma del vrshest\u00e1 constituido por una \u00fanica mol\u00e9cula de rnade polaridad negativa, no segmentada que codifica 11 prote\u00ednas v\u00edrales. la protelna f del virus respiratorio sincitial humano media la fusi\u00f3n de las membranas viral y celular. Es una glicoproteina tipo i que se sintetiza como un precursor inactivo (fo)que, posteriormente, experimenta un doble corte proteolitico dando lugar a dos cadenas (f1 y f2) unidas por puentes disulfuro. Preparaciones de proteinas f y ftm- (carece de la regi\u00f3n transmembrana) vistas al microscopio electr\u00f3nico, presentan dos tipos de conformaciones: conos y varillas con cabeza globular. En el caso de la prote\u00edna ftm-, los conos son formas no agregadas y las varillas con cabeza globular son agregados en forma de rosetas. El tratamiento de esta prote\u00edna con tripslna, hace que \u00fanicamente aparezcan rosetas formadas por varillas con cabeza globular. este cambio estructural se debe al doble procesamiento del precursor que no ocurre eficentemente en el interior de la c\u00e9lula. La agregaci\u00f3n de la prote\u00edna ftm-probablemente ocurre por \u00ednteracciones entre los p\u00e9pt\u00eddos de fus\u00ed\u00f3n de mol\u00e9culas ftm-que son expuestos tras el completo procesamiento proteol\u00edtico. Debido a que la exposici\u00f3n del p\u00e9ptido de fusi\u00f3n es un evento clave en el proceso de fusi\u00f3n de membranas, los cambios asociados con el procesamiento de ftm-serian un buen reflejo de lo que ocurriria en la proteina f tras su activaci\u00f3n para la fusi\u00f3n de membranas. Con el fin de estudiar en detalle los requerimientos del p\u00e9ptido de fusi\u00f3n para ios cambios asociados al procesamiento de la prote\u00edna fm- y la fusi\u00f3n de membranas, se intr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Requerimientos del p\u00e9ptido de fusi\u00f3n para la funcionalidad de la prote\u00edna f del virus respiratorio sincitial humano vrsh<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Requerimientos del p\u00e9ptido de fusi\u00f3n para la funcionalidad de la prote\u00edna f del virus respiratorio sincitial humano vrsh <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diana Mart\u00edn Lorenzo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Melero Fondevilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Montero camerero <\/li>\n<li>enrique Villar ledesma (vocal)<\/li>\n<li>Juan Ort\u00edn monz\u00f3n (vocal)<\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diana Mart\u00edn Lorenzo El virus respiratorio sincitial humano (vrsh)es el principal agente causante de infecciones graves del 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