{"id":7498,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/terapia-genica-experimental-transferencia-del-gen-humano-alfa-1-antitripsina-a-hepatocitos-de-raton-in-vivo\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"terapia-genica-experimental-transferencia-del-gen-humano-alfa-1-antitripsina-a-hepatocitos-de-raton-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/terapia-genica-experimental-transferencia-del-gen-humano-alfa-1-antitripsina-a-hepatocitos-de-raton-in-vivo\/","title":{"rendered":"Terapia genica experimental: transferencia del gen humano alfa 1-antitripsina a hepatocitos de raton \u00abin vivo\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaime Crespo Perez <\/strong><\/h2>\n<p>En el presente trabajo se muestra que la transferencia \u00abin vivo\u00bb del gen humano alfa 1-antitripsina a hepatocitos de raton, utilizando liposomas peque\u00f1os, es un procedimiento facil y efectivo para inducir la produccion de la proteina humana en dichos hepatocitos.  asimismo, se demuestra que esta transferencia es un proceso selectivo, condicionado por el tama\u00f1o de los liposomas. Los liposomas peque\u00f1os son sistemas transportadores con una alta afinidad, puesto que se requieren dosis muy peque\u00f1as del material genetico encapsulado, para alcanzar efectos maximos. Tambien se observa que la hepatectomia parcial aumenta la biodisponibilidad del material genetico transferido, ya que incrementa y prolonga los niveles plasmaticos de la proteina humana. Por otro lado, se demuestra que tanto los liposomas peque\u00f1os anionicos como los cationicos son capaces de inducir la produccion de la proteina humana.  este trabajo sugiere que la terapia genica puede ser sustitutiva de los metodos terapeuticos actuales, aunque se requiere desarrollar construcciones genicas con mayor capacidad de expresion y\/o sistemas de transferencia que aumenten la biodisponibilidad del material genetico transferido a las celulas diana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia genica experimental: transferencia del gen humano alfa 1-antitripsina a hepatocitos de raton \u00abin vivo\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia genica experimental: transferencia del gen humano alfa 1-antitripsina a hepatocitos de raton \u00abin vivo\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaime Crespo Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Francisco Ali\u00f1o Pellicer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Esplugues Requena <\/li>\n<li>Antonio Garcia Garcia (vocal)<\/li>\n<li>Santiago Grisolia Garcia (vocal)<\/li>\n<li>Jaime Piulats Xanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaime Crespo Perez En el presente trabajo se muestra que la transferencia \u00abin vivo\u00bb del gen humano [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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