{"id":75171,"date":"2018-03-09T23:20:18","date_gmt":"2018-03-09T23:20:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-receptor-cannabinoide-cb1-en-la-regulacion-de-la-ansiedad-implicacion-en-la-eficacia-terapeutica-de-farmacos-ansiola%c2%adticos\/"},"modified":"2018-03-09T23:20:18","modified_gmt":"2018-03-09T23:20:18","slug":"papel-del-receptor-cannabinoide-cb1-en-la-regulacion-de-la-ansiedad-implicacion-en-la-eficacia-terapeutica-de-farmacos-ansiola%c2%adticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-del-receptor-cannabinoide-cb1-en-la-regulacion-de-la-ansiedad-implicacion-en-la-eficacia-terapeutica-de-farmacos-ansiola%c2%adticos\/","title":{"rendered":"Papel del receptor cannabinoide cb1 en la regulaci\u00f3n de la ansiedad. implicaci\u00f3n en la eficacia terap\u00e9utica de f\u00e1rmacos ansiol\u00edticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leyre Uriguen Echevarria <\/strong><\/h2>\n<p>Resumen: el desarrollo, en la \u00faltima d\u00e9cada, de numerosos estudios empleando a9-tetrahidrocannabinol(thc), el principio activo del cannabis, o diferentes agonistas sint\u00e9ticos del reqeptor cannabinoide, ha contribuido de manera muy significativa al avance en el conocimiento de las acciones farmacol\u00f3gicas y los procesos neurobiol\u00f3gicos implicados en la activaci\u00f3n de receptores cannabinoides. Este espectacular avance ha permitido identificar 1m nuevo sistema de neurotransmisi\u00f3n compuesto por dos tipos de receptores cannabinoides: el receptor cb1, localizado fundamentalmenteen sistema nervioso central y el receptor cb2, con funciones relacionadas.Con la regulaci\u00f3n del sistema inmunitario. Adem\u00e1s, se . Han identificado varios ligandos end\u00f3gen()s (la anandamida y el 2-araquidonil-glicerol)y un sistema enzim\u00e1tico (amidohidrolasa de \u00e1cidos grasos) que permitela finalizaci\u00f3nde las accionesde estos ligandosen las sinapsis.  los estudios precl\u00ednicos y cl\u00ednicos relacionados con el consumo de thc o de agonistas del receptor cannabinoide sugieren que el sistema cannabinoide end\u00f3geno desempe\u00f1a un papel relevante en la regul\u00e1ci\u00f3n del estado de ansiedad. esta idea se fundamenta en las alteraciones neuroqu\u00edmicas y comportamentales que se producen en los animales de experimentaci\u00f3n y en el hombre tras el consumo agudo o cr\u00f3nico de derivados de cannabis, tales como alteraciones en la regulaci\u00f3n neuroendocrina del eje hipot\u00e1lamo hip\u00f3fisis adrenal (hha), modificaciones en la expresi\u00f3nde genes asociadosal control de la respuesta al estr\u00e9s y aumentode la reactividadconductual y neuroqu\u00edmicaante est\u00edmulosansiog\u00e9nicos. la colocalizaci\u00f3n de receptores cannabinoides cb1 con receptores gaba\u00e9rgicos y serotonin\u00e9rgicos en neuronas de \u00e1reas cerebrales  \u00edntimamente ligadas a la regulaci\u00f3n de la ansiedad, como el hipocampo y la am\u00edgdala, sugiere que las alteraciones en la funcionalidad de receptores  cannabinoides puede, del mismo mod<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del receptor cannabinoide cb1 en la regulaci\u00f3n de la ansiedad. implicaci\u00f3n en la eficacia terap\u00e9utica de f\u00e1rmacos ansiol\u00edticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del receptor cannabinoide cb1 en la regulaci\u00f3n de la ansiedad. implicaci\u00f3n en la eficacia terap\u00e9utica de f\u00e1rmacos ansiol\u00edticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leyre Uriguen Echevarria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Manzanares Robles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li>Fernando Berrendero d\u00edaz (vocal)<\/li>\n<li>Miguel Gutierrez fraile (vocal)<\/li>\n<li>Jos\u00e9 Javier Meana Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leyre Uriguen Echevarria Resumen: el desarrollo, en la \u00faltima d\u00e9cada, de numerosos estudios empleando a9-tetrahidrocannabinol(thc), el principio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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