{"id":75277,"date":"2005-01-07T00:00:00","date_gmt":"2005-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-chettaphanin-i-ent-agezasina-e-y-analogos-de-picrasanos-a-partir-de-acido-ent-halimico\/"},"modified":"2005-01-07T00:00:00","modified_gmt":"2005-01-07T00:00:00","slug":"sintesis-de-chettaphanin-i-ent-agezasina-e-y-analogos-de-picrasanos-a-partir-de-acido-ent-halimico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-chettaphanin-i-ent-agezasina-e-y-analogos-de-picrasanos-a-partir-de-acido-ent-halimico\/","title":{"rendered":"Sintesis de chettaphanin i, ent-agezasina e y analogos de picrasanos a partir de acido ent-halimico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Garcia Calvo <\/strong><\/h2>\n<p>En la presente memoria, a partir de \u00e1cido ent-hal\u00edmico (componente mayoritario de halimium viscosum, villarino de los aires), se describe la s\u00edntesis del producto natural chettaphanin i, se realiza una aproximaci\u00f3n sint\u00e9tica a triterpenos degradados de esqueleto picrasano y se lleva a cabo la s\u00edntesis del diterpeno-alcaloide ent-agelasina c.  el chettaphanin i es el primer producto natural de esqueleto de ent-halimano conocido, aislado de adenochlaena siamensis, planta utilizada en medicina tradicional. Estructuralmente es un furanoditerpeno con varias funciones oxigenadas lo que le hace muy interesante desde el punto de vista sint\u00e9tico. su s\u00edntesis ha permitido corroborar su estructura y establecer su configuraci\u00f3n absoluta.  el inter\u00e9s de los quassinoides de esqueleto picrasano es bien conocido debido a la amplia gama de actividades biol\u00f3gicas que presentan. En la aproximaci\u00f3n sint\u00e9tica realizada de estos compuestos, el sistema bic\u00edclico del \u00e1cido ent-hal\u00edmico se incorpora como parte bc de un sistema tric\u00edclico abc. Para la construcci\u00f3n del anillo a se han estudiado dos rutas alternativas, seg\u00fan sea la posici\u00f3n c-3 nucle\u00f3fila o electr\u00f3fila. Despu\u00e9s de una ciclaci\u00f3n mediante condensaci\u00f3n ald\u00f3lica intramolecular, se consigue el sistema tric\u00edclico. adem\u00e1s se ha abierto una nueva v\u00eda para llegar, en el futuro a la formaci\u00f3n del anillo d obteni\u00e9ndose por tanto el sistema abcd de los picrasanos.  agelasina c y epi-agelasina c son diterpeno-alcaloides de origen marino que presentan diferentes actividades biol\u00f3gicas: antimicrobiales, inhibidores de la enzima na,k-atpasa y antiadherentes. La s\u00edntesis de ent-agelasina c, a partir de \u00e1cido ent-hal\u00edmico y adenina ha permitido corregir las estructuras propuestas para dichos productos naturales. Por comparaci\u00f3n de las propiedades f\u00edsicas y espectrosc\u00f3picas del producto de s\u00edntesis con las de los productos naturales, se ha llegado a establecer la estructura y co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de chettaphanin i, ent-agezasina e y analogos de picrasanos a partir de acido ent-halimico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de chettaphanin i, ent-agezasina e y analogos de picrasanos a partir de acido ent-halimico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Garcia Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Sanchez Marcos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda del carmen Avenda\u00f1o l\u00f3pez <\/li>\n<li>Jos\u00e9 ram\u00f3n Pedro llinares (vocal)<\/li>\n<li>Andr\u00e9s Garcia granado lopez del hierro (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Miguel del corral santana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Garcia Calvo En la presente memoria, a partir de \u00e1cido ent-hal\u00edmico (componente mayoritario de halimium viscosum, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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