{"id":75278,"date":"2005-01-07T00:00:00","date_gmt":"2005-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-nuevos-insulinomimeticos-animas-sensibles-a-ssao-e-insulinosecretores-ligandos-imidazolinicos-i2\/"},"modified":"2005-01-07T00:00:00","modified_gmt":"2005-01-07T00:00:00","slug":"estudio-farmacologico-de-nuevos-insulinomimeticos-animas-sensibles-a-ssao-e-insulinosecretores-ligandos-imidazolinicos-i2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-nuevos-insulinomimeticos-animas-sensibles-a-ssao-e-insulinosecretores-ligandos-imidazolinicos-i2\/","title":{"rendered":"Estudio farmacologico de nuevos insulinomimeticos (animas sensibles a ssao) e insulinosecretores (ligandos imidazolinicos i2)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Francisca Pastor Mansilla <\/strong><\/h2>\n<p>1) se ha visto que los compuestos con estructura de imidazolina (i) estimulan la secreci\u00f3n de insulina en islotes pancre\u00e1ticos aislados y que mejoran la tolerancia a la glucosa en ratas y ratones. Pero, la naturaleza de los sitios de uni\u00f3n involucrados en la respuesta secretora de insulina no est\u00e1 a\u00fan clara. Teniendo en cuenta la elevada presencia de receptores imidazol\u00ednicos en los tejidos de conejo, hemos elegido este animal como modelo experimental para esta tesis para re-evaluar en nuestro modelo los efectos de los ligandos imidazol\u00ednicos: efarox\u00e1n, idazox\u00e1n, metoxidazox\u00e1n y bu224. Los experimentos han sido realizados tanto in vivo (test de tolerancia a glucosa) como in vitro (islotes aislados frescos en incubaci\u00f3n est\u00e1tica y perifusi\u00f3n). Los resultados obtenidos en la tesis indican la presencia de lugares que median en los efectos de las imidazolinas en la secreci\u00f3n de insulina: un sitio com\u00fan localizado en el poro del canal katp  y otro sitio de uni\u00f3n i2 no-mitocondrial  2) los substratos de la amino-oxidasa sensible a semicarbazida (ssao) han sido descritos como agentes insulinomim\u00e9ticos. De esta forma, se ha publicado que la combinaci\u00f3n de benzilamina con vanadato estimula el transporte de glucosa en adipocitos de rata y mejora la captaci\u00f3n de glucosa en ratas normogluc\u00e9micas y diab\u00e9ticas. En la tesis, vemos que benzilamina (substrato s\u00edntetico) y metilamina (end\u00f3geno) por s\u00ed mismas (sin vanadato) reducen la glucemia e inhiben la lip\u00f3lisis en conejos. Estos resultados se han obtenido realizando test de tolerancia a la glucosa y mediendo la secreci\u00f3n de insulina de islotes aislados y la actividad lipol\u00edtica de adipocitos aislados. A la vista de los resultados obtenidos: ambas aminas mejoran la captaci\u00f3n de glucosa tanto in vivo como in vitro sin estimular la secreci\u00f3n de insulina; consider\u00e1ndose a las aminas sensibles a ssao como un grupo de f\u00e1rmacos con potenciales propiedades antihipergluc\u00e9micas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de nuevos insulinomimeticos (animas sensibles a ssao) e insulinosecretores (ligandos imidazolinicos i2)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de nuevos insulinomimeticos (animas sensibles a ssao) e insulinosecretores (ligandos imidazolinicos i2) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Francisca Pastor Mansilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Moratinos Areces<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Jimenez fern\u00e1ndez <\/li>\n<li>Francisco Javier Garcia sancho martin (vocal)<\/li>\n<li>deborah Burks (vocal)<\/li>\n<li>Antonio Zorzano olarte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Francisca Pastor Mansilla 1) se ha visto que los compuestos con estructura de imidazolina (i) estimulan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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