{"id":75323,"date":"2005-04-07T00:00:00","date_gmt":"2005-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencias-de-la-catalasa-y-de-la-beta-toxina-en-la-patogenesis-de-staphylococcus-aureus\/"},"modified":"2005-04-07T00:00:00","modified_gmt":"2005-04-07T00:00:00","slug":"influencias-de-la-catalasa-y-de-la-beta-toxina-en-la-patogenesis-de-staphylococcus-aureus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/influencias-de-la-catalasa-y-de-la-beta-toxina-en-la-patogenesis-de-staphylococcus-aureus\/","title":{"rendered":"Influencias de la catalasa y de la beta toxina en la patog\u00e9nesis de staphylococcus aureus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Mart\u00ednez Pulgar\u00edn <\/strong><\/h2>\n<p>S. Aureus es un microorganismo ubicuo causante de diversas enfermedades tanto en el hombre como en los animales dom\u00e9sticos. En medicina veterinaria destaca principalmente por su implicaci\u00f3n en las infecciones intramamarias, que ocasionan importantisimas p\u00e9rdidas econ\u00f3micas en la producci\u00f3n bovina, ovina y caprina. En los \u00faltimos a\u00f1os se ha puesto de manifiesto que s. aureus es capaz  de intemalizarse, sobrevivir y, en ocasiones, multiplicarse en diferentes tipos celulares, incluidas c\u00e9lulas fagociticas, pudiendo contribuir este hecho a la persistencia de la infecci\u00f3n en el organismo al proteger a la bacteria de la actividad del sistema inmune y de los tratamientos antibi\u00f3ticos y facilitar su diseminaci\u00f3n. Esta supervivencia intracelular puede estar detellllinada por la capacidad de s. Aureus para hacer frente a la acci\u00f3n bactericida derivada del metabolismo oxidativo de las c\u00e9lulas eucariotas. en bacterias como m. Tuberculosis, c. Jejuni y h. Pylori se ha demostrado que la catalasa, una enzima responsable de la degradaci\u00f3n del per\u00f3xido de hidr\u00f3geno generado durante este metabolismo en agua y ox\u00edgeno molecular, es un factor esencial para su supervivencia en elinterior de diversos tipos celulares, sin embargo, en s. Aureus no se ha determinado con precisi\u00f3n hasta la fecha el posible papel de esta enzima en su patog\u00e9nesis. Igualmente, la beta-toxina, una enzima que act\u00faa degradando la esfingomielina presente en las membranas celulares, podria ser importante durante el ciclo de vida intracelular de s. Aureus, participando, al igual que otras esfingomielinasas bacterianas, en la ruptura de la vacuola fagocitica, y posterior liberaci\u00f3n de la bacteria al citoplasma de la c\u00e9lula infectada, y en la inducci\u00f3n de apoptosis celular a trav\u00e9s de la liberaci\u00f3n de ceramida. No obstante, la posible contribuci\u00f3n de la beta-toxina a la patog\u00e9nesis de s. Aureus no se ha demostrado concluyentemente hasta la fecha.  bas\u00e1ndonos en e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencias de la catalasa y de la beta toxina en la patog\u00e9nesis de staphylococcus aureus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencias de la catalasa y de la beta toxina en la patog\u00e9nesis de staphylococcus aureus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Mart\u00ednez Pulgar\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo De La Fuente L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Ruiz santa quiteria serrano de la cruz Jos\u00e9 Antonio <\/li>\n<li>xavier Rubies feijoo (vocal)<\/li>\n<li>el\u00edas Fernando Rodriguez ferri (vocal)<\/li>\n<li>Jos\u00e9 Rafael Penades casanova (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Mart\u00ednez Pulgar\u00edn S. Aureus es un microorganismo ubicuo causante de diversas enfermedades tanto en el hombre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,2391],"tags":[2718,46742,5395,131823,162881,83288],"class_list":["post-75323","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-microbiologia-veterinaria","tag-elias-fernando-rodriguez-ferri","tag-jose-rafael-penades-casanova","tag-ricardo-de-la-fuente-lopez","tag-ruiz-santa-quiteria-serrano-de-la-cruz-jose-antonio","tag-susana-Martinez-pulgarin","tag-xavier-rubies-feijoo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=75323"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75323\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=75323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=75323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=75323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}