{"id":75377,"date":"2005-05-07T00:00:00","date_gmt":"2005-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-anti-vih-de-plantas-de-la-comunidad-de-madrid-aislamiento-de-principios-activos\/"},"modified":"2005-05-07T00:00:00","modified_gmt":"2005-05-07T00:00:00","slug":"actividad-anti-vih-de-plantas-de-la-comunidad-de-madrid-aislamiento-de-principios-activos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/actividad-anti-vih-de-plantas-de-la-comunidad-de-madrid-aislamiento-de-principios-activos\/","title":{"rendered":"Actividad anti-vih de plantas de la comunidad de Madrid aislamiento de principios activos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Miguel Bedoya Del Olmo <\/strong><\/h2>\n<p>Se seleccionaron 25 plantas de la zona centro de la pen\u00ednsula ib\u00e9rica con el fin de estudiar su actividad anti-vih.Cuatro especies, tres cistaceae,citus lurifolius, cistus monspeliensis y tuberaria lignosa y una rosaceae, sanguisorba minor, demostraron poseer dicha actividad cuando se analizaron sus extractos acuoso y etan\u00f3licos.El extracto acuoso y el etan\u00f3lico de tuberaria lingnosa presentaron mayor actividad que los extractos de las otras tres especies por lo que se procedi\u00f3 a su fraccionamiento pudi\u00e9ndose aislar los compuestos responsables de la actividad.Estos resultados ser taninos hidrolizables , tres de ellos  denominados 1a,sr2 y tl3.A3s264 elagitaninos simple y uno , denominado dg21, un tamino hidrolizable de alto peso molecular.  se estableci\u00f3 el mecanismo de acci\u00f3n de estos compuestos utilizando virus recombinantes,portadores del gen indicador de la luciferasa.Los resultados muestran como tanto los elagitaninos aislados de tuberaria lignosa como el tanino hidrolizable de alto peso molecular presentaban el mismo modo de acci\u00f3n,y actuaban bloqueando la entrada del vih en la c\u00e9lula.Se pudo demostrar que esos compuestos inhiben la entrada de virus con tropismo tanto r5 como x4 y que su mecanismo de acci\u00f3n era especifico del vih.La internalizaci\u00f3n del receptor principal para la entrada del vih en la c\u00e9lula linfoide, el cd4, se demostr\u00f3 para un elagitanino simple, el 1a, y para un tanino de alto peso molecular, el dg21, pudiendo ser el mecanismo responsable de la actividad anti-vih de este tipo de compuesto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad anti-vih de plantas de la comunidad de Madrid aislamiento de principios activos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad anti-vih de plantas de la comunidad de Madrid aislamiento de principios activos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Miguel Bedoya Del Olmo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paulina Bermejo Benito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sonsoles Sanchez palomino <\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>\u00e1ngel Villar del fresno (vocal)<\/li>\n<li>tomas Pumarola su\u00f1e (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Miguel Bedoya Del Olmo Se seleccionaron 25 plantas de la zona centro de la pen\u00ednsula ib\u00e9rica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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