{"id":75424,"date":"2005-06-07T00:00:00","date_gmt":"2005-06-07T00:00:00","guid":{"rendered":""},"modified":"2005-06-07T00:00:00","modified_gmt":"2005-06-07T00:00:00","slug":"modulacion-de-la-conjugacion-y-la-actividad-citola%c2%adtica-de-celulas-nk-efecto-del-tratamiento-con-anticuerpos-monoclonales-frente-a-integrinas-beta-1-en-celulas-diana-y-anti-mhc-i-en-celulas-efec","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-conjugacion-y-la-actividad-citola%c2%adtica-de-celulas-nk-efecto-del-tratamiento-con-anticuerpos-monoclonales-frente-a-integrinas-beta-1-en-celulas-diana-y-anti-mhc-i-en-celulas-efec\/","title":{"rendered":"Modulaci\u00f3n de la conjugaci\u00f3n y la actividad citol\u00edtica de c\u00e9lulas nk. efecto del tratamiento con anticuerpos monoclonales frente a integrinas beta-1 en c\u00e9lulas diana y anti-mhc-i en c\u00e9lulas efectoras."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Ferez Ruiz <\/strong><\/h2>\n<p>Resumen: el objetivo general planteado en esta tesis ha sido explorar sistemas de modulaci\u00f3n positiva y\/o negativa del proceso citot\u00f3xico de c\u00e9lulas nk mediante el empleo de anticuerpos monoclonales. Hemos estudiado por una parte, la funci\u00f3n de las integrinas beta-1 (cd29) expresadas en la membrana de diferentes c\u00e9lulas diana y por otra, el papel del propio mhc-i expresado en la c\u00e9lula efectora, lo que hemos denominado \u00abmhc-i self\u00bb, tanto desde el punto de vista funcional (procesos de conjugaci\u00f3n y actividad citot\u00f3xica), topol\u00f3gico (localizaci\u00f3n en la superficie celular con respecto a los \u00abrafts\u00bb y a la sinapsis inmunol\u00f3gica) y ontog\u00e9nico (la expresi\u00f3n de mhc-i y dx5 (cd49b) puede determinar y diferenciar etapas de su proceso vital). Para analizar parte de los datos obtenidos hemos dise\u00f1ado un procedimiento nomalizado para el an\u00e1lisis estad\u00edstico de la colocalizaci\u00f3n de dos o m\u00e1s mol\u00e9culas de membranas celulares. Los resultados han mostrado que la se\u00f1alizaci\u00f3n inducida a trav\u00e9s de las integrinas beta-1 (residuos 207-218) expresadas en c\u00e9lulas leuc\u00e9micas incrementa la susceptibilidad (conjugaci\u00f3n y lisis) a la citotoxicidad mediada por c\u00e9lulas nk; que la agregaci\u00f3n de las mol\u00e9culas mhc-i con anticuerpos monoclonales en las c\u00e9lulas nk inhibe la capacidad de conjugaci\u00f3n y lisis frente a k562, excluye las prote\u00ednas mhc-i de la sinapsis inmunol\u00f3gica y de los \u00abrafts\u00bb e induce la fosforilaci\u00f3n intracelular de tirosinas. Por \u00faltimo, se ha caracterizado una subpoblaci\u00f3n de c\u00e9lulas nk de rat\u00f3n de fenotipo nk1.1+, dx5- que podr\u00eda pertenecer a un estad\u00edo terminal del linaje nk.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la conjugaci\u00f3n y la actividad citol\u00edtica de c\u00e9lulas nk. efecto del tratamiento con anticuerpos monoclonales frente a integrinas beta-1 en c\u00e9lulas diana y anti-mhc-i en c\u00e9lulas efectoras.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la conjugaci\u00f3n y la actividad citol\u00edtica de c\u00e9lulas nk. efecto del tratamiento con anticuerpos monoclonales frente a integrinas beta-1 en c\u00e9lulas diana y anti-mhc-i en c\u00e9lulas efectoras. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Ferez Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Pilar Garc\u00eda Pe\u00f1arrubia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Celada cotarelo <\/li>\n<li>francesco Colucci (vocal)<\/li>\n<li> Alvarez l\u00f3pez Mar\u00eda roc\u00edo (vocal)<\/li>\n<li>trinidad Hernandez caselles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Ferez Ruiz Resumen: el objetivo general planteado en esta tesis ha sido explorar sistemas de modulaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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