{"id":75428,"date":"2005-06-07T00:00:00","date_gmt":"2005-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-efecto-supresor-de-c3g-en-la-transformacion-inducida-por-el-oncogen-hras\/"},"modified":"2005-06-07T00:00:00","modified_gmt":"2005-06-07T00:00:00","slug":"caracterizacion-del-efecto-supresor-de-c3g-en-la-transformacion-inducida-por-el-oncogen-hras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-del-efecto-supresor-de-c3g-en-la-transformacion-inducida-por-el-oncogen-hras\/","title":{"rendered":"Caracterizacion del efecto supresor de c3g en la transformacion inducida por el oncogen hras"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Martin Encabo <\/strong><\/h2>\n<p>Mi trabajo se ha basado en caracterizar el efecto supresor de c3g sobre la transformaci\u00f3n inducida por el oncog\u00e9n hras. La prote\u00edna c3g es un intercambiador de nucle\u00f3tidos de guanina (gef) de rap1 y r-ras que posee dominios funcionales hom\u00f3logos a otros gefs de la familia ras, como son los dominios cdc25 (o regi\u00f3n catal\u00edtica), rem y el dominio rico en prolinas sh3-b (o de uni\u00f3n a crk) (tanaka et al., 1994). A pesar de que rap1 es un antagonista de la transformaci\u00f3n inducida por k-ras (sakoda et al., 1992), c3g es capaz de reducir el n\u00famero de focos inducido por hras, c-sis, v-raf en c\u00e9lulas nih 3t3 independientemente de la activaci\u00f3n de rap1(guerrero et al., 1998).  hemos identificado que la funci\u00f3n supresor de c3g est\u00e1 asociado al dominio sh3-b y suprime la transformaci\u00f3n inducida por varios oncogenes como, dbl y r-ras pertenecientes a varias rutas de se\u00f1alizaci\u00f3n lo que determina su efecto generalizado.  en concreto, el mecanismo de supresi\u00f3n ejercido por c3g sobre la transformaci\u00f3n inducida por ras se basa en reducir los niveles de erk fosforilado, posiblemente a trav\u00e9s de la activaci\u00f3n de fosfatasas asociadas, ya que no modifica el estado de activaci\u00f3n de los dem\u00e1s miembros que est\u00e1n por encima de erk de la ruta de ras-erk. Tambi\u00e9n la sobreexpresi\u00f3n de c3g reduce los niveles de expresi\u00f3n de ciclina a, lo que posiblemente resulta en una disminuci\u00f3n de los niveles de rb fosforilado y una menor capacidad de crecimiento independiente de anclaje al sustrato. Adem\u00e1s la sobreexpresi\u00f3n de c3g tambi\u00e9n inhibe la ruta de pi3k-akt, pero este efecto no est\u00e1 relacionado con la actividad supresora sobre la transformaci\u00f3n de ras. C3g se localiza en el golgi y en la regi\u00f3n subcortical del citoesqueleto de actina, siendo en esta \u00faltima regi\u00f3n subcelular d\u00f3nde posiblemente c3g ejerce su efecto supresor sobre la transformaci\u00f3n oncog\u00e9nica, quiz\u00e1s a trav\u00e9s de su interacci\u00f3n con la actina. Los niveles de c3g present<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion del efecto supresor de c3g en la transformacion inducida por el oncogen hras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion del efecto supresor de c3g en la transformacion inducida por el oncogen hras <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Martin Encabo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Miguel Angel Santos De Dios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Rojas caba\u00f1eros <\/li>\n<li>almudena Porras gallo (vocal)<\/li>\n<li> Sacristan martin Mar\u00eda  de la paz (vocal)<\/li>\n<li>Juan  pedro Bola\u00f1os hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Martin Encabo Mi trabajo se ha basado en caracterizar el efecto supresor de c3g sobre la 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