{"id":75504,"date":"2005-08-07T00:00:00","date_gmt":"2005-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-descriptores-moleculares-basados-en-cadenas-de-markov-estudios-de-relacion-estructura-propiedad-y-bioinformatica\/"},"modified":"2005-08-07T00:00:00","modified_gmt":"2005-08-07T00:00:00","slug":"nuevos-descriptores-moleculares-basados-en-cadenas-de-markov-estudios-de-relacion-estructura-propiedad-y-bioinformatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-descriptores-moleculares-basados-en-cadenas-de-markov-estudios-de-relacion-estructura-propiedad-y-bioinformatica\/","title":{"rendered":"Nuevos descriptores moleculares basados en cadenas de markov: estudios de relaci\u00f3n estructura-propiedad y bioinform\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Humberto Gonz\u00e1lez D\u00edaz <\/strong><\/h2>\n<p>En esta tesis se ha corroborado la importancia de los estudios te\u00f3ricos qsar en el desarrollo farmac\u00e9utico. En este sentido, se desarrollaron representaciones unificadas de algunos grupos descriptores moleculares y se definieron por primera vez los descriptores moleculares basados en \u00abcadenas de jarkov\u00bb (cm). Se desarroll\u00f3 adem\u00e1s una interpretaci\u00f3n fisicoqu\u00edmica de los mismos en analog\u00eda con la termodin\u00e1mica. Dichos descriptores son aplicados a estudios osar d\u00e1ndose ejemplos reales de su eficacia en el descubrimiento de nuevos compuestos activos, y su capacidad de predicci\u00f3n de algunos valores toxicol\u00f3gicos experimentales y de distribuci\u00f3n. Los nuevos modelos usando descriptores basados en cm fueron comparados con otros estudios qsar referidos en la bibliograf\u00eda o en este trabajo obteni\u00e9ndose resultados positivos.  se introdujeron nuevos descriptores moleculares que codifican distintos niveles de la estructura macromolecular de las prote\u00ednas teniendo en cuenta la secuencia, la informaci\u00f3n parcialmente 3d, la estructura 3d o la estructura superficial. Dichos descriptores se aplicaron a estudios qsar con prote\u00ednas y se compararon con otros referidos en la literatura obteni\u00e9ndose resultados excelentes. Se introducen nuevos descriptores moleculares que codifican distintos niveles de la estructura macromolecular de los \u00e1cidos nucleicos, con especial \u00e9nfasis en la estructura secundaria del arn. Dichos descriptores son aplicados a estudios locales de interacci\u00f3n f\u00e1rmaco-arn y estudios bioinform\u00e1ticos. Los modelos desarrollados fueron comparados con \u00e9xito frente a otros aportados por la literatura. Adem\u00e1s, algunas de las predicciones fueron corroboradas experimentalmente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos descriptores moleculares basados en cadenas de markov: estudios de relaci\u00f3n estructura-propiedad y bioinform\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos descriptores moleculares basados en cadenas de markov: estudios de relaci\u00f3n estructura-propiedad y bioinform\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Humberto Gonz\u00e1lez D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Uriarte Villares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Estevez cabanas <\/li>\n<li> Cabrera p\u00e9rez Miguel \u00e1ngel (vocal)<\/li>\n<li>fernanda Borges (vocal)<\/li>\n<li>ricardo Mosquera castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Humberto Gonz\u00e1lez D\u00edaz En esta tesis se ha corroborado la importancia de los estudios te\u00f3ricos qsar en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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