{"id":75516,"date":"2005-08-07T00:00:00","date_gmt":"2005-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-composicion-estructura-y-funcion-de-las-glicoprotea%c2%adnas-de-la-zona-pelucida-con-especial-referencia-a-la-especie-humana\/"},"modified":"2005-08-07T00:00:00","modified_gmt":"2005-08-07T00:00:00","slug":"analisis-de-la-composicion-estructura-y-funcion-de-las-glicoprotea%c2%adnas-de-la-zona-pelucida-con-especial-referencia-a-la-especie-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-la-composicion-estructura-y-funcion-de-las-glicoprotea%c2%adnas-de-la-zona-pelucida-con-especial-referencia-a-la-especie-humana\/","title":{"rendered":"An\u00e1lisis de la composici\u00f3n estructura y funci\u00f3n de las glicoprote\u00ednas de la zona pel\u00facida con especial referencia a la especie humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Jim\u00e9nez Movilla <\/strong><\/h2>\n<p>En la presente tesis doctoral se han estudiados diferentes aspectos relacionados con la composici\u00f3n gluc\u00eddica, estructura, formaci\u00f3n y origen de la zona pel\u00facida y las glicoprote\u00ednas que la forman, poniendo especial inter\u00e9s en la especie humana. Para este prop\u00f3sito hemos desarrollado tres l\u00edneas principales de investigaci\u00f3n, estudio ultraestructural de la zona pel\u00facida y gr\u00e1nulos corticales de ovocitos humanos y de la s\u00edntesis de las glicoprote\u00ednas de la zp humana y de rat\u00f3n, an\u00e1lisis bioqu\u00edmico y biof\u00edsico de las glicoprote\u00ednas de la zona pel\u00facida de h\u00e1mster y an\u00e1lisis bioqu\u00edmico y fisiol\u00f3gico de zp2 y zp3 recombinantes humanas expresadas en c\u00e9lulas cho. A continuaci\u00f3n se presenta un resumen de los experimentos realizados y datos obtenidos en la tres l\u00edneas de investigaci\u00f3n.  1. Se ha realizado un estudio ultraestructural de la zona pel\u00facida y gr\u00e1nulos corticales de ovocitos humanos para determinar su composici\u00f3n gluc\u00eddica y estructura. Igualmente hemos investigado, a nivel ultraestructural, la posible ruta de s\u00edntesis de las glicoprote\u00ednas que forman la zp humana y la estructura de las organelas implicadas en la s\u00edntesis de glicoprote\u00ednas en los diferentes estados de desarrollo de los fol\u00edculos de ovocitos de rat\u00f3n. Para ello hemos utilizado t\u00e9cnicas citoqu\u00edmicas a nivel de microscopia electr\u00f3nica aplicando lectinas conjugadas con peroxidasa, digoxigenina y oro coloidal en combinaci\u00f3n con tratamientos enzim\u00e1ticos. Tambi\u00e9n se han utilizado t\u00e9cnicas inmunocitoqu\u00edmicas con anticuerpos dirigidos contra glicoprote\u00ednas constituyentes de la zp humana y contra prote\u00ednas marcadores de organelas presentes en el citoplasma de ovocitos de rat\u00f3n. Los estudios comparativos cuantitativos se han realizado mediante an\u00e1lisis de imagen. los principales resultados obtenidos en el presente estudio pueden ser agrupados en los siguientes apartados:  a.- La zp humana de ovocitos en vg y mii presenta afinidad po<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la composici\u00f3n estructura y funci\u00f3n de las glicoprote\u00ednas de la zona pel\u00facida con especial referencia a la especie humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la composici\u00f3n estructura y funci\u00f3n de las glicoprote\u00ednas de la zona pel\u00facida con especial referencia a la especie humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Jim\u00e9nez Movilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Aviles Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepci\u00f3n Cazorla ferrer <\/li>\n<li>riccardo Focerelli (vocal)<\/li>\n<li>pilar Coy fuster (vocal)<\/li>\n<li>Emilio G\u00f3mez s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jim\u00e9nez Movilla En la presente tesis doctoral se han estudiados diferentes aspectos relacionados con la composici\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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