{"id":75533,"date":"2005-08-07T00:00:00","date_gmt":"2005-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-nuevos-petidomimeticos-fuorados\/"},"modified":"2005-08-07T00:00:00","modified_gmt":"2005-08-07T00:00:00","slug":"sa%c2%adntesis-de-nuevos-petidomimeticos-fuorados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesis-de-nuevos-petidomimeticos-fuorados\/","title":{"rendered":"S\u00edntesis de nuevos petidomim\u00e9ticos fuorados"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Chiva T\u00e1rrega Gemma Mar\u00eda <\/strong><\/h2>\n<p>Los p\u00e9ptidos son de gran inter\u00e9s en medicina ya que se pueden utilizar para el tratamiento de las enfermedades en las que est\u00e1n implicados. Como resultado de los avances en qu\u00edmica terap\u00e9utica y biolog\u00eda molecular, muchos p\u00e9ptidos activos han sido preparados en grandes cantidades y adaptados para experimentos cl\u00ednicos y farmacol\u00f3gicos. Particularmente interesantes en el campo de s\u00edntesis de peptidomim\u00e9ticos farmacol\u00f3gicamanete activos son los p\u00e9ptidos retro y retro-inversos. Por otra parte, en el campo de la s\u00edntesis de peptidomim\u00e9ticos es cada vez mayor el inter\u00e9s por los a- y \u00edY-amino\u00e1cidos fluorados. Teniendo en cuenta estos dos aspectos, uno de los objetivos de la tesis doctoral ha sido la s\u00edntesis estereoselectiva de retro-peptidomim\u00e9ticos ? [Nhch2] parcialmente modificados fluorados que incorporan un sustituto estable de la trifluoroalanina   en disoluci\u00f3n, fase s\u00f3lida y en fase fluorosa.  otro de los objetivos llevados a cabo en la realizaci\u00f3n de la tesis  doctoral es la s\u00edntesis de otras dos familias de peptidomim\u00e9ticos: peptidomim\u00e9ticos con la agrupaci\u00f3n urea y peptidomim\u00e9ticos con la agrupaci\u00f3n a-trifluorometil \u00edY2-alanina.  el \u00faltimo de los objetivos de este trabajo ha sido la determinaci\u00f3n mediante c\u00e1lculos te\u00f3ricos del mecanismo y del origen de la diastereoselectividad de la reacci\u00f3n aza-michael utilizada para la s\u00edntesis de estos peptidomim\u00e9ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de nuevos petidomim\u00e9ticos fuorados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de nuevos petidomim\u00e9ticos fuorados <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Chiva T\u00e1rrega Gemma Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santos Fustero Lardi\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Mouri\u00f1o mosquera <\/li>\n<li>claudio Palomo nicolau (vocal)<\/li>\n<li>enrique Aguilar huergo (vocal)<\/li>\n<li>pedro Jos\u00e9 Campos Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Chiva T\u00e1rrega Gemma Mar\u00eda Los p\u00e9ptidos son de gran inter\u00e9s en medicina ya que se pueden utilizar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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