{"id":75594,"date":"2005-11-07T00:00:00","date_gmt":"2005-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-sistema-natriuretico-en-la-retina-humana-posible-implicacion-del-peptido-atrial-natriuretico-en-la-retinopata%c2%ada-diabetica\/"},"modified":"2005-11-07T00:00:00","modified_gmt":"2005-11-07T00:00:00","slug":"expresion-del-sistema-natriuretico-en-la-retina-humana-posible-implicacion-del-peptido-atrial-natriuretico-en-la-retinopata%c2%ada-diabetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expresion-del-sistema-natriuretico-en-la-retina-humana-posible-implicacion-del-peptido-atrial-natriuretico-en-la-retinopata%c2%ada-diabetica\/","title":{"rendered":"Expresi\u00f3n del sistema natriur\u00e9tico en la retina humana, posible implicaci\u00f3n del p\u00e9ptido atrial natriur\u00e9tico en la retinopat\u00edadiab\u00e9tica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Rollin Toledo <\/strong><\/h2>\n<p>En este trabajo se detecto la expresi\u00f3n de los tr\u00e1nscritos de los receptores de los p\u00e9ptidos natriur\u00e9ticos (npra, nprb, y nprc), junto con la expresi\u00f3n de arnm de anp , bnp y cnp en la retina humana de sujetos controles, proporcionando evidencias  de la existencia de un sistema natriur\u00e9tico local.Los niveles de expresi\u00f3n g\u00e9nica medidos por rt-pcr cuantitativa a tiempo real, mostraron que no existen deferencias significativas entre los diferentes subtipos de receptores de los p\u00e9ptidos natriur\u00e9ticos en la retina humana de sujetos controles.La expresi\u00f3n de los p\u00e9ptidos natriur\u00e9ticos se detect\u00f3 por inmunohistoqu\u00edmica en estructuras vasculares,gliales (astrocitos)y neurales de la retina adulta normal, lo que sugiere una funci\u00f3n de los p\u00e9ptidos natriur\u00e9ticos en preservar tanto la integridad vascular como la neural de la retina madura.  en la diabetes mellitus,la expresi\u00f3n del anp retiniano var\u00eda en funci\u00f3n del estado metab\u00f3lico y del grado de isquemia retiniana en paralelo con los cambios de la expresi\u00f3n del gfap en las capas m\u00e1s internas de la retina.Los m\u00e1s relevante de este estudio ha sido el hallazgo de que en la retinopat\u00eda diab\u00e9tica proliferativa la se\u00f1al inmuorreactiva del anp desaparece (en paralelo con una disminuci\u00f3n de astrocitos)mientras que el tratamiento con l\u00e1ser aumenta la se\u00f1al del anp junto con la de la gl\u00eda reactiva(astrocitos y c\u00e9lulas de m\u00ed\u00bcller).Estos datos sugieren que el anp podr\u00eda ejercer una funci\u00f3n antiangiog\u00e9nica en la retinopat\u00eda diab\u00e9tica proliferativa posiblemente inhibiendo la producci\u00f3n del vegf o la activaci\u00f3n por este \u00faltimo factor de mol\u00e9culas implicadas en la angiog\u00e9nesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n del sistema natriur\u00e9tico en la retina humana, posible implicaci\u00f3n del p\u00e9ptido atrial natriur\u00e9tico en la retinopat\u00edadiab\u00e9tica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n del sistema natriur\u00e9tico en la retina humana, posible implicaci\u00f3n del p\u00e9ptido atrial natriur\u00e9tico en la retinopat\u00edadiab\u00e9tica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Rollin Toledo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Fern\u00e1ndez Durango<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fern\u00e1ndez cruz p\u00e9rez arturo <\/li>\n<li>Marta Suarez leoz (vocal)<\/li>\n<li> Perez gozmariz rosa m. (vocal)<\/li>\n<li>Luis felipe Pallardo sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Rollin Toledo En este trabajo se detecto la expresi\u00f3n de los tr\u00e1nscritos de los receptores de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,35],"tags":[43242,14834,102584,163370,61056,163369],"class_list":["post-75594","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-ciencias-de-la-vida","tag-fernandez-cruz-perez-arturo","tag-luis-felipe-pallardo-sanchez","tag-marta-suarez-leoz","tag-perez-gozmariz-rosa-m","tag-raquel-fernandez-durango","tag-raquel-rollin-toledo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=75594"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75594\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=75594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=75594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=75594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}