{"id":75718,"date":"2018-03-09T23:21:02","date_gmt":"2018-03-09T23:21:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-sdf-1-y-tgf-beta1-en-la-invasion-y-adhesion-celular\/"},"modified":"2018-03-09T23:21:02","modified_gmt":"2018-03-09T23:21:02","slug":"papel-de-sdf-1-y-tgf-beta1-en-la-invasion-y-adhesion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-sdf-1-y-tgf-beta1-en-la-invasion-y-adhesion-celular\/","title":{"rendered":"Papel de sdf-1 y tgf-beta1 en la invasi\u00f3n y adhesi\u00f3n celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Alvaro Bartolome Conde <\/strong><\/h2>\n<p>Resumen: la invasi\u00f3n de tejidos por c\u00e9lulas tumorales implica su migraci\u00f3n a trav\u00e9s de membranas basales mediante una activaci\u00f3n coordinada de la degradaci\u00f3n de la matriz y de mecanismos de locomoci\u00f3n celular. Las quimioquinas proporcionan gu\u00edasquimot\u00e1cticas hacia distintos \u00f3rganos y, por tanto, podr\u00edan participar potencialmente en la diseminaci\u00f3n de c\u00e9lulas tumorales. Aqu\u00ed mostramos que varias l\u00edneas de melanoma y c\u00e9lulas de melanoma de g\u00e1nglios linf\u00e1ticos expresan los receptores de quimioquinas cxcr4 y cxcr3, y que sus ligandos, cxcl12 (sdf-1) y cxcl9 (mig), promueven la invasi\u00f3n de c\u00e9lulas de melanoma a trv\u00e9s de membranas basales. La actividad proteol\u00edtica de mt1-mmpera necesaria para estas invasiones, y cxcl12induc\u00eda un incremento en la expresi\u00f3n de mt1-mmp.Adem\u00e1s cxcl12 y cxcl9 promueven la activaci\u00f3n de las gtpasas rhoa y rac, y la expresi\u00f3n de formas dominantes negativas de estas gtpasas inhib\u00edan la invasi\u00f3n de los transfectantes en respuesta a ambas quimioquinas. Encontramos adem\u00e1s que las c\u00e9lulas de melanomaexpresan vav1yvav2,que son prote\u00ednas gefque catalizan la activaci\u00f3nde gtpasas rho.Cxcl12 induce la activaci\u00f3n de vav1 y vav2, y la interferencia de la expresi\u00f3n de estas gef se tradujo en una inhibici\u00f3n de la activaci\u00f3n de rhoa y rac, el aumento de expresi\u00f3n de mt1-mmp,y la invasi\u00f3n de c\u00e9lulas de melanoma en respuesta a cxcl12. Adicionalmente, la expresi\u00f3n de cxcr4 en las c\u00e9lulas de melanoma fue notablemente aumentada por tgf.~1, un componente de las membranas basales, y anticuerpos anti-tgf-b inhibieron este aumento de expresi\u00f3n de cxcr4, as\u00ed como la invasi\u00f3n de c\u00e9lulas de melanoma hacia cxcl12. la estimulaci\u00f3n por cxcl12 de la ruta vav\/gtpasas rho\/mt1-mmpen las c\u00e9lulas de melanoma, as\u00ed como la regulaci\u00f3n de la expresi\u00f3n de cxcr4, constituyen mecanismos que contribuyen a la invasi\u00f3n de c\u00e9lulas de melanoma hacia cxcl12. nuestros resultados proporcionan la base para futuras inve<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de sdf-1 y tgf-beta1 en la invasi\u00f3n y adhesi\u00f3n celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de sdf-1 y tgf-beta1 en la invasi\u00f3n y adhesi\u00f3n celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Alvaro Bartolome Conde <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Teixid\u00f3 Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>angeles Garc\u00eda pardo (vocal)<\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li>Carlos Caba\u00f1as guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Alvaro Bartolome Conde Resumen: la invasi\u00f3n de tejidos por c\u00e9lulas tumorales implica su migraci\u00f3n a trav\u00e9s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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