{"id":75726,"date":"2018-03-09T23:21:02","date_gmt":"2018-03-09T23:21:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-fipronil-sobre-neurotransmisores-monoaminergicos-en-el-sistema-nervioso-central-de-la-rata\/"},"modified":"2018-03-09T23:21:02","modified_gmt":"2018-03-09T23:21:02","slug":"efectos-del-fipronil-sobre-neurotransmisores-monoaminergicos-en-el-sistema-nervioso-central-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-del-fipronil-sobre-neurotransmisores-monoaminergicos-en-el-sistema-nervioso-central-de-la-rata\/","title":{"rendered":"Efectos del fipronil sobre neurotransmisores monoamin\u00e9rgicos en el sistema nervioso central de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ren\u00e9 Pita Pita <\/strong><\/h2>\n<p>El fipronil es un plaguicida de descubrimiento y comercializaci\u00f3n relativamente reciente que act\u00faa como un potente bloqueante de los receptores gaba\u00e9rgicos asociados a canales de iones cloruro, con m\u00e1s selectividad sobre los receptores de insectos que sobre los receptores de mam\u00edferos. Sin embargo, la posible existencia de otros mecanismos de acci\u00f3n neurot\u00f3xicos del fipronil en mam\u00edferos no ha sido estudiada. Los signos de intoxicaci\u00f3n por fipronil en mam\u00edferos incluyen anorexia, letargo y convulsiones cl\u00f3nico-t\u00f3nicas. Es dif\u00edcil explicar todo el espectro de la actividad neurot\u00f3xica del fipronil simplemente en t\u00e9rminos de un mecanismo gaba\u00e9rgico. Puesto que muchas observaciones evidencian que los sistemas catecolamin\u00e9rgico y serotonin\u00e9rgico est\u00e1n implicados en los procesos convulsivos, el presente trabajo de investigaci\u00f3n tiene como objetivo el estudio de las posibles alteraciones en estos sistemas de neurotransmisores monoamin\u00e9rgicos en regiones del snc de ratas wistar expuestas a dosis m\u00faltiples de fipronil (5; 10 y 15 mg\/kg p.C.\/D\u00eda, durante 5 d\u00edas). El fipronil alter\u00f3 en el snc los niveles de serotonina (5-ht) y de su metabolito el \u00e1cido 5-hidroxi-3-indolac\u00e9tico (5-hiaa), as\u00ed como los niveles de dopamina (da) y de sus metabolitos el \u00e1cido 3,4-dihidroxifenilac\u00e9tico (dopac) y el \u00e1cido homovan\u00edlico (hva).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del fipronil sobre neurotransmisores monoamin\u00e9rgicos en el sistema nervioso central de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del fipronil sobre neurotransmisores monoamin\u00e9rgicos en el sistema nervioso central de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ren\u00e9 Pita Pita <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Ramon Anadon Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li>david Ordo\u00f1ez escudero (vocal)<\/li>\n<li>arturo Hardisson de la torre (vocal)<\/li>\n<li>octavio Perez luzardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ren\u00e9 Pita Pita El fipronil es un plaguicida de descubrimiento y comercializaci\u00f3n relativamente reciente que act\u00faa como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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