{"id":75729,"date":"2018-03-09T23:21:02","date_gmt":"2018-03-09T23:21:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-de-los-inhibidores-de-la-hmg-co-a-reductasa-en-la-proliferacion-de-celulas-normales-y-tumorales-cultivadas-in-vitro-y-en-la-modulacion-de-farmacos-antineoplasicos\/"},"modified":"2018-03-09T23:21:02","modified_gmt":"2018-03-09T23:21:02","slug":"estudio-de-la-actividad-de-los-inhibidores-de-la-hmg-co-a-reductasa-en-la-proliferacion-de-celulas-normales-y-tumorales-cultivadas-in-vitro-y-en-la-modulacion-de-farmacos-antineoplasicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-de-los-inhibidores-de-la-hmg-co-a-reductasa-en-la-proliferacion-de-celulas-normales-y-tumorales-cultivadas-in-vitro-y-en-la-modulacion-de-farmacos-antineoplasicos\/","title":{"rendered":"Estudio de la actividad de los inhibidores de la hmg-co a reductasa en la proliferaci\u00f3n de c\u00e9lulas normales y tumorales cultivadas in vitro y en la modulaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Ortiz Vega <\/strong><\/h2>\n<p>Introducci\u00f3n     el colesterol es un componente importante de las membranas celulares, y es esencial para el crecimiento y viabilidad celular. La etapa limitante de la bios\u00edtnesis del colesterol est\u00e1 limitada por la enzima hmg-co a reductasas. las estatinas son inhibidores competitivos de la hmg-co a reductasa, y se utilizan en el tratamiento de la hipercolesterolemia. Algunos de los denominados efectos pleiotr\u00f3picos de las estatinas podr\u00edan ser \u00fatiles en el tratamiento de otras patolog\u00edas.  objetivos     en el presente trabajo tratamos de valorar la actividad antiproliferativa de las estatinas (atorvastatina, cerivastatina, lovastatina, pravastatina y simvastatina) y su posible efecto modulador sobre diversos quimioter\u00e1picos antineopl\u00e1sicos (adriamicina, cisplatino, docetaxel, 5-fluoracilo, gemcitabina, mitomicina-c. Mitoxantrona, taxol, vincristina) en c\u00e9lulas cultivadas in vitro tanto normales (fibroblastos) como tumorales (melanoma maligno: adld, neuroblastoma: shsy5y, carcinoma de cuello uterino: hela, adenocarcinoma de colon: ht-29).  material y m\u00e9todos     cultivos de tejidos de c\u00e9lulas normales y tumorales. T\u00e9cnicas citol\u00f3gicas. Microscop\u00eda de fluorescencia. Microscop\u00eda digital de intervalos y ensayos predictivos de quimiosensibilidad.  resutlados y conclusiones     los inhibidores de la hidroxi-metil-glutaril-coa-reductasa (estatinas) provocan en todas las l\u00edneas celulares estudiadas inhibici\u00f3n de la proliferaci\u00f3n celular e inducci\u00f3n de apoptosis. Adicionalmente, las estatinas inducen modificaciones en la cin\u00e9tica del crecimiento celular, habiendo observado sincronizaci\u00f3n de las c\u00e9lulas en fase g del ciclo celular, as\u00ed como un incremento del tiempo de generaci\u00f3n y de la duraci\u00f3n de las mitosis. La pr\u00e1ctica totalidad de estos efectos se inhiben o revierten con la supresi\u00f3n del tratamiento, la adici\u00f3n de mevalonato, \u00f3 con la adici\u00f3n de lipoprote\u00ednas. Las c\u00e9lulas tumorales m\u00e1s sensibles fueron las de neuroblasto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad de los inhibidores de la hmg-co a reductasa en la proliferaci\u00f3n de c\u00e9lulas normales y tumorales cultivadas in vitro y en la modulaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad de los inhibidores de la hmg-co a reductasa en la proliferaci\u00f3n de c\u00e9lulas normales y tumorales cultivadas in vitro y en la modulaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Ortiz Vega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ismael Alvarez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda   teresa Tejerina sanchez <\/li>\n<li>Juan a Rubles prats (vocal)<\/li>\n<li>Manuel Oya otero (vocal)<\/li>\n<li>Manuel Jos\u00e9 Gayoso rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Ortiz Vega Introducci\u00f3n el colesterol es un componente importante de las membranas celulares, y es esencial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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