{"id":75736,"date":"2018-03-09T23:21:02","date_gmt":"2018-03-09T23:21:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-oxido-nitrico-exogeno-en-el-trasplante-renal-homologo-experimental-viabilidad-celular-y-respuesta-inflamatoria\/"},"modified":"2018-03-09T23:21:02","modified_gmt":"2018-03-09T23:21:02","slug":"el-oxido-nitrico-exogeno-en-el-trasplante-renal-homologo-experimental-viabilidad-celular-y-respuesta-inflamatoria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-oxido-nitrico-exogeno-en-el-trasplante-renal-homologo-experimental-viabilidad-celular-y-respuesta-inflamatoria\/","title":{"rendered":"El oxido nitrico exogeno en el trasplante renal homologo experimental. viabilidad celular y respuesta inflamatoria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Ortega Casanueva <\/strong><\/h2>\n<p>En el mundo se realizan 35.000 trasplantes renales al a\u00f1o. El coste de la hemodi\u00e1lisis es semejante al coste del trasplante renal en el primer a\u00f1o. En a\u00f1os sucesivos, el coste del trasplante renal es un 20% del coste de la di\u00e1lisis se le a\u00f1ade al factor econ\u00f3mico, la calidad y la cantidad de vida, queda justificado cualquier programa bien estructurado de trasplante renal.  la ciclosporina a, contribuye de forma decisiva al \u00e9xito del trasplante al disminuir el rechazo mediante la inmunosupresi\u00f3n  pero a pesar de los avances la infecci\u00f3n y la toxicidad obstaculizan el \u00e9xito del trasplante. la respuesta  inflamatoria, asociada a respuesta inmune, es un importante mecanismo asociado al fracaso funcional del \u00f3rgano trasplantado. En la respuesta inflamatoria en el trasplante renal hay que tener en cuenta la lesi\u00f3n por isquemia y la lesi\u00f3n por reperfusi\u00f3n, la cual puede dar lugar a alteraciones m\u00e1s graves que las inducidas por la propia isquemia. En el modelo de isquemia reperfusi\u00f3n se ha comprobado como los tejidos sometidos a periodos cortos de isquemia separados por periodos de repercusi\u00f3n intermitente, toleran mejor periodos prolongados de isquemia.  nuestra hip\u00f3tesis es  que el tratamiento profil\u00e1ctico con el donador de \u00f3xido n\u00edtrico molsidomina, en un modelo experimental de trasplante renal hom\u00f3logo heterot\u00f3pico, regular\u00e1 la respuesta inflamatoria permitiendo tiempos prolongados de preservaci\u00f3n y mejor funci\u00f3n org\u00e1nica post-trasplante. Valorar las alteraciones en los mediadores bioqu\u00edmicos, moleculares y gen\u00e9ticos de la respuesta inflamatoria, estudiar el grado de lesi\u00f3n renal y su funci\u00f3n post-trasplante y demostrar la efectividad del tratamiento propuesto. Para nuestro estudio se ha utilizado el cerdo minipig macho  y se han observado las variable de mortalidad,creatinina y su aclaramiento,estudio histol\u00f3gico microscopico y electr\u00f3nico,actividad de la mieloperoxidasa,citocinas proinflamatorias ( il 1 y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El oxido nitrico exogeno en el trasplante renal homologo experimental. viabilidad celular y respuesta inflamatoria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El oxido nitrico exogeno en el trasplante renal homologo experimental. viabilidad celular y respuesta inflamatoria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Ortega Casanueva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Criado Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li>Jos\u00e9 Ortega bevia (vocal)<\/li>\n<li>bruno Camps vilata (vocal)<\/li>\n<li>Jes\u00fas Fernandez crespo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Ortega Casanueva En el mundo se realizan 35.000 trasplantes renales al a\u00f1o. El coste de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,9386],"tags":[9244,11541,163620,68465,125317,26439],"class_list":["post-75736","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-salamanca","tag-alberto-gomez-alonso","tag-bruno-camps-vilata","tag-cristina-ortega-casanueva","tag-garcia-criado-francisco-javier","tag-jesus-fernandez-crespo","tag-jose-ortega-bevia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=75736"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75736\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=75736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=75736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=75736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}