{"id":75750,"date":"2018-03-09T23:21:02","date_gmt":"2018-03-09T23:21:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-del-mecanismo-funcional-de-ariadne-1a-de-drosophila-melanogaster\/"},"modified":"2018-03-09T23:21:02","modified_gmt":"2018-03-09T23:21:02","slug":"identificacion-del-mecanismo-funcional-de-ariadne-1a-de-drosophila-melanogaster","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histologia-animal\/identificacion-del-mecanismo-funcional-de-ariadne-1a-de-drosophila-melanogaster\/","title":{"rendered":"Identificaci\u00f3n del mecanismo funcional de ariadne-1a de drosophila melanogaster"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gradilla Castellanos Ana Citlali <\/strong><\/h2>\n<p>La subfamilia de prote\u00ednas ariadne, pertenece a la familia de prote\u00ednas rbr (ring finger-in between ring fingers-ring finger) que funcionan como enzimas ligasa de ubiqutina e3 mediante su interacci\u00f3n con enzimas e2. En drosophila melanogaster existen tres, adriadne-1a, 1b y 2. En este trabajo, estudiamos el papel de ariadne-1a como enzima e3 en el contexto del organismo; finalizando con un primer acercamiento a las relaciones funcionales entre esta prote\u00edna y los otros miembros de la subfamilia ariadne. Anteriormente, se defini\u00f3 que la falta de funci\u00f3n de ariadne-1a es letal durante la pupaci\u00f3n; nosotros encontramos que este fen\u00f3meno se repite en el caso del exceso de funci\u00f3n, indicando que la estequiometr\u00eda de esta prote\u00edna es primordial. En el estadio de pupa se da lugar a la metamorfosis y este proceso est\u00e1 regulado por la v\u00eda de se\u00f1alizaci\u00f3n de la ecdisona. la ecdisona regula la expresi\u00f3n de genes durante el desarrollo mediante su uni\u00f3n a sus receptores nucleares, principalmente el heterod\u00edmero formado por el receptor de ecdisona y el receptor nuclear ultraspiracles. Existen tres isoformas del receptor de ecdisona, las cuales mediante su expresi\u00f3n diferencial confieren especificidad temporal y espacial a la se\u00f1alizaci\u00f3n hormonal. Durante el desarrollo de esta tesis, hemos encontrado que araiadne-1a est\u00e1 involucrada en la v\u00eda de la ecdisona regulando a la isoforma a del receptor de ecdisona.  por otro lado, comprobamos que el fenotipo de reducci\u00f3n de ret\u00edculo endopl\u00e1smico descrito para mutantes puntuales de ariadne-1a tambi\u00e9n se produce en mutaciones nulas, corroborando la importancia funcional de los motivos estructurales ring finger, adem\u00e1s, analizamos este fenotipo  en el exceso de funci\u00f3n y curiosamente se produce un incrementos en el tama\u00f1o de este org\u00e1nulo al aumentar la cantidad de producto. Finalmente, describimos que la deficiencia de aridane-1a reduce la resistencia al estr\u00e9s oxidativo producido por metales pesados y e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n del mecanismo funcional de ariadne-1a de drosophila melanogaster<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n del mecanismo funcional de ariadne-1a de drosophila melanogaster <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gradilla Castellanos Ana Citlali <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Ferr\u00fas Gamero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Aranda iriarte <\/li>\n<li>Miguel angel Vidal caballero (vocal)<\/li>\n<li>sonsoles Campuzano corrales (vocal)<\/li>\n<li>ignacio Mar\u00edn lozano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gradilla Castellanos Ana Citlali La subfamilia de prote\u00ednas ariadne, pertenece a la familia de prote\u00ednas rbr (ring [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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