{"id":75782,"date":"2018-03-09T23:21:06","date_gmt":"2018-03-09T23:21:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-actividad-quitin-sintasa-iii-en-levaduras\/"},"modified":"2018-03-09T23:21:06","modified_gmt":"2018-03-09T23:21:06","slug":"regulacion-de-la-actividad-quitin-sintasa-iii-en-levaduras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-la-actividad-quitin-sintasa-iii-en-levaduras\/","title":{"rendered":"Regulacion de la actividad quitin sintasa iii en levaduras"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Sanz Vicente <\/strong><\/h2>\n<p>La pared celular f\u00fangica constituye el exoesqueleto de hongos y levaduras, determinando su morfolog\u00eda y participando en numerosos procesos celulares. al ser exclusiva de hongos y esencial para su supervivencia, representa una excelente diana para el dise\u00f1o de antif\u00fangicos con toxicidad selectiva.  la quitina es un pol\u00edmero minoritario de la pared pero constituye un elemento estructural esencial para la supervivencia f\u00fangica. Su s\u00edntesis es llevada a cabo por las actividades quit\u00edn sintasas (qs).  este trabajo est\u00e1 centrado en el estudio de los mecanismos moleculares implicados en la regulaci\u00f3n de la actividad qsiii en la levadura saccharomyces cerevisiae y en el hongo pat\u00f3geno candida albicans.  hemos demostrado que en s. Cerevisiae la prote\u00edna bni4p es necesaria para la localizaci\u00f3n temprana del complejo qsiii en el cuello asegurando el correcto ensamblaje del anillo de quitina, aunque tambi\u00e9n desarrolla funciones adicionales relacionadas con el ensamblaje del septo celular.  la prote\u00edna shc1p se ha identificado como un activador de la qsiii espec\u00edfico de esporulaci\u00f3n, siendo imprescindible para la correcta maduraci\u00f3n de las ascosporas a trav\u00e9s de su participaci\u00f3n en la s\u00edntesis de la capa de quitos\u00e1n. es por tanto funcionalmente redundante con chs4p, el activador\/localizador de la qsiii durante el crecimiento vegetativo. Ambos est\u00e1n diferencialmente regulados por una combinaci\u00f3n de mecanismos transcripcionales y postraduccionales que permiten que no coincidan temporalmente en la c\u00e9lula.  c. Albicans posee un hom\u00f3logo funcional de chs7p, regulador clave de la actividad qsiii. Esto implica una conservaci\u00f3n funcional en la regulaci\u00f3n de la qsiii. El estudio de este gen ha demostrado que en c. Albicans la quitina qsiii-dependiente no es requerida para el crecimiento ni la miceliaci\u00f3n, pero desempe\u00f1a un papel esencial en el mantenimiento de la integridad de la pared celular. Esta integridad es necesaria para<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la actividad quitin sintasa iii en levaduras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la actividad quitin sintasa iii en levaduras <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Sanz Vicente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>C\u00e9sar Roncero Ma\u00edllo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Gonzalez roncero <\/li>\n<li>Jes\u00fas Pla alonso (vocal)<\/li>\n<li>Manuel Mu\u00f1iz guinea (vocal)<\/li>\n<li>Mar\u00eda  del pilar Perez gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Sanz Vicente La pared celular f\u00fangica constituye el exoesqueleto de hongos y levaduras, determinando su morfolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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