{"id":75789,"date":"2018-03-09T23:21:06","date_gmt":"2018-03-09T23:21:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-ige-mediada-de-la-ciclooxigenasa-2-y-la-interleuquina-8-en-leucocitos-humanos\/"},"modified":"2018-03-09T23:21:06","modified_gmt":"2018-03-09T23:21:06","slug":"regulacion-ige-mediada-de-la-ciclooxigenasa-2-y-la-interleuquina-8-en-leucocitos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alergias\/regulacion-ige-mediada-de-la-ciclooxigenasa-2-y-la-interleuquina-8-en-leucocitos-humanos\/","title":{"rendered":"Regulaci\u00f3n ige-mediada de la ciclooxigenasa-2 y la interleuquina-8 en leucocitos humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Chac\u00f3n Fern\u00e1ndez Pedro Jos\u00e9 <\/strong><\/h2>\n<p>Aunque la alergia es una enfermedad descrita en el hombre a principios del siglo xx, sus causas y mecanismos a\u00fan est\u00e1n en estudio. desde hace a\u00f1os se conoce que las reacciones al\u00e9rgicas o at\u00f3picas se originan, en los individuos que la sufren, como consecuencia de una reacci\u00f3n inmune \u00abequivocada\u00bb frente a sustancias extra\u00f1as o alergenos y que est\u00e1n mediadas por inmunoglobulinas de tipo e sintetizadas contra estos alergenos (ige). esta ige desempe\u00f1a su funci\u00f3n en la superficie de c\u00e9lulas inmunes efectoras (linfocitos, macr\u00f3fagos, eosin\u00f3filos, bas\u00f3filos y neutr\u00f3filos). A ellas se une a trav\u00e9s de receptores espec\u00edficos (fc epsilon ri, fcepsilon rii y galectina-3), provocando la activaci\u00f3n de las mismas, que se traduce en la liberaci\u00f3n de mediadores inflamatorios. los protaglandinas son mediadores liposolubles sintetizados por oxigenaci\u00f3n del \u00e1cido araquid\u00f3nico, por acci\u00f3n de los enzimas ciclooxigenasas (coxs). Existen dos tipos de coxs: la cox-1 es expresada de forma constitutiva en la mayor\u00eda de los tejidos y es la responsable de la generaci\u00f3n de prostaglandinas que regulan condiciones fisiol\u00f3gicas normales (la secreci\u00f3n g\u00e1strica, por ejemplo); en cambio cox-2 no aparece expresada en condiciones normales en los tejidos, y puede ser inducidas en condiciones inflamatorias, de estr\u00e9s, etc. Cada vez hay m\u00e1s datos que sugieren que la inducci\u00f3n de la cox-2 y la s\u00edntesis de prostaglandinas por la misma, puede ser un elemento clave en el estado fisiopatol\u00f3gico de un gran n\u00famero de des\u00f3rdenes, entre los que se encuentra la alergia.     la il-8 es una citoquina con capacidad proinflamatoria, debida a su principal funci\u00f3n: es quimiot\u00e1ctica (atrayente en funci\u00f3n de gradiente qu\u00edmico) para c\u00e9lulas inmunes. Adem\u00e1s presenta caracter\u00edsticas angiog\u00e9nicas y mitog\u00e9nicas. Por esta raz\u00f3n se ha asociado c on un gran n\u00famero de patolog\u00edas que cursan con inflamaci\u00f3n, como las reacciones al\u00e9rgicas.     en este estudio demostramos que linfo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n ige-mediada de la ciclooxigenasa-2 y la interleuquina-8 en leucocitos humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n ige-mediada de la ciclooxigenasa-2 y la interleuquina-8 en leucocitos humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Chac\u00f3n Fern\u00e1ndez Pedro Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Sobrino Beneyto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos manuel Ruiz de galarreta hern\u00e1ndez <\/li>\n<li>consuelo Santamar\u00eda p\u00e9rez (vocal)<\/li>\n<li>josefina Hidalgo jim\u00e9nez (vocal)<\/li>\n<li>Alberto Vargas morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Chac\u00f3n Fern\u00e1ndez Pedro Jos\u00e9 Aunque la alergia es una enfermedad descrita en el hombre a principios del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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