{"id":75794,"date":"2018-03-09T23:21:06","date_gmt":"2018-03-09T23:21:06","guid":{"rendered":""},"modified":"2018-03-09T23:21:06","modified_gmt":"2018-03-09T23:21:06","slug":"efectos-electrofisiologicos-miocardicos-intra%c2%adnsecos-producidos-por-la-inhibicion-del-sistema-de-intercambio-sodio-proton-en-condiciones-de-normoxia-y-tras-la-isquemia-miocardica-regional-estu","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-electrofisiologicos-miocardicos-intra%c2%adnsecos-producidos-por-la-inhibicion-del-sistema-de-intercambio-sodio-proton-en-condiciones-de-normoxia-y-tras-la-isquemia-miocardica-regional-estu\/","title":{"rendered":"Efectos electrofisiol\u00f3gicos mioc\u00e1rdicos intr\u00ednsecos producidos por la inhibici\u00f3n del sistema de intercambio sodio-prot\u00f3n, en condiciones de normoxia, y tras la isquemia mioc\u00e1rdica regional. estudio experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Such Miquel <\/strong><\/h2>\n<p>Hemos realizado un estudio, encaminado a investigar un aspecto del efecto protector de la inhibici\u00f3n del intercambiador na+\/h+ (nhe) sobre el miocardio isqu\u00e9mico, a nivel tanto de la refractariedad, como de la inducibilidad de la fibrilaci\u00f3n ventricular (fv). Por otra parte, se ha investigado si la inhibici\u00f3n del mencionado sistema de intercambio modifica, en condiciones de perfusi\u00f3n normalmente oxigenada, por mecanismos intr\u00ednsecos, el automatismo sinusal, la conducci\u00f3n auriculoventricular (av), y la refractariedad auricular, ventricular y del sistema de conducci\u00f3n auriculoventricular. Asimismo, se ha analizado como una propiedad electrofisiol\u00f3gica adicional, y en las condiciones de perfusi\u00f3n mioc\u00e1rdica citadas, la frecuencia dominante de la fv.  se ha realizado el estudio en coraz\u00f3n aislado de conejo, con la t\u00e9cnica de langendorff. Los conejos se anestesiaron, heparinizaron y tras su sacrificio se les extrajo el coraz\u00f3n para ubicarlo en el sistema de perfusi\u00f3n a trav\u00e9s de la arteria aorta a presi\u00f3n de perfusi\u00f3n, con el l\u00edquido nutricio carbogenado, de 60 mm de h2o y 37\u00c2\u00ba c. Se ubic\u00f3 un electrodo de registro auricular, otro de estimulaci\u00f3n auricular, y un electrodo de estimulaci\u00f3n ventricular. para los registros ventriculares se aplic\u00f3 sobre el ventr\u00edculo izquierdo un electrodo m\u00faltiple con 256 electrodos unipolares. Los electrodos de registro se conectaron a un sistema de mapeo de la actividad el\u00e9ctrica (maptech), y los de estimulaci\u00f3n a un sistema de estimulaci\u00f3n programada. para inhibir el intercambiador nhe se us\u00f3 el 5-(n-etil-n-isoprpil) amiloride (eipa) a concentraciones 0,4 y 1  m. En coraz\u00f3n con oclusi\u00f3n coronaria, se analiz\u00f3: 1) inducibilidad de la fv con extraest\u00edmulos y 2) periodos refractarios, efectivo y funcional, ventriculares. En coraz\u00f3n normalmente oxigenado se analiz\u00f3: 1) refractariedad efectiva y funcional auricular, ventricular y del sistema de conducci\u00f3n av. 2) frecuencia dominante<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos electrofisiol\u00f3gicos mioc\u00e1rdicos intr\u00ednsecos producidos por la inhibici\u00f3n del sistema de intercambio sodio-prot\u00f3n, en condiciones de normoxia, y tras la isquemia mioc\u00e1rdica regional. estudio experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos electrofisiol\u00f3gicos mioc\u00e1rdicos intr\u00ednsecos producidos por la inhibici\u00f3n del sistema de intercambio sodio-prot\u00f3n, en condiciones de normoxia, y tras la isquemia mioc\u00e1rdica regional. estudio experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Such Miquel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lu\u00eds Such Belenguer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Lopez merino <\/li>\n<li>Juan Cos\u00edn aguilar (vocal)<\/li>\n<li>Juan  Antonio Ruiperez abizanda (vocal)<\/li>\n<li>Antonio Iradi casal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Such Miquel Hemos realizado un estudio, encaminado a investigar un aspecto del efecto protector de la 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