{"id":75848,"date":"2018-03-09T23:21:10","date_gmt":"2018-03-09T23:21:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hipoxia-tisular-en-los-sarcomas-osteoblasticos-sobre-la-supervivencia-papel-de-la-expresion-proteica-de-hif-1a-vegf-y-del-17b-estradiol\/"},"modified":"2018-03-09T23:21:10","modified_gmt":"2018-03-09T23:21:10","slug":"efecto-de-la-hipoxia-tisular-en-los-sarcomas-osteoblasticos-sobre-la-supervivencia-papel-de-la-expresion-proteica-de-hif-1a-vegf-y-del-17b-estradiol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-hipoxia-tisular-en-los-sarcomas-osteoblasticos-sobre-la-supervivencia-papel-de-la-expresion-proteica-de-hif-1a-vegf-y-del-17b-estradiol\/","title":{"rendered":"Efecto de la hipoxia tisular en los sarcomas osteoblasticos sobre la supervivencia: papel de la expresi\u00f3n proteica de hif-1\u00aa, vegf y del 17b estradiol."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Ram\u00edrez S\u00e1nchez <\/strong><\/h2>\n<p>Existe un gran paralelismo entre los fen\u00f3menos tumorales \u00f3seos con los fen\u00f3menos de curaci\u00f3n y consolidaci\u00f3n de las fracturas y con las alteraciones del desarrollo del aparato locomotor. En todos ellos acontecen fen\u00f3menos de desdiferenciaci\u00f3n celular, que condicionan mayor producci\u00f3n de matriz extracelular, fen\u00f3menos hip\u00f3xicos e incrementos en la vascularizaci\u00f3n tisular. entender en profundidad estos fen\u00f3menos celulares, comunes en los procesos anteriormente citados, es esencial para el mejor conocimiento de procesos nosol\u00f3gicos, como son las fracturas \u00f3seas, los tumores malignos del aparato locomotor o las alteraciones en el desarrollo del mismo.  el objetivo del presente trabajo es evaluar en qu\u00e9 medida las alteraciones en la vascularizaci\u00f3n de los osteosarcomas, provocado por una hipoxia en el mismo, condiciona la conducta biol\u00f3gica de los mismos. Para ello se plantea estudiar in vivo, en muestras de pacientes afectos de osteosarcoma, as\u00ed como in vitro, cu\u00e1l es el papel de las alteraciones en la vascularizaci\u00f3n tumoral en la conducta de estas neoplasias.  describimos c\u00f3mo la hipoxia incrementa la expresi\u00f3n proteica de determinados marcadores tumorales (hif-1a, vegf), aumenta la neo-vascularizaci\u00f3n tumoral, la tendencia a provocar met\u00e1stasis y, con todo ello, a disminuir la tasa de supervivencia de los pacientes. Todos estos efectos se hallan bajo el control de los estr\u00f3genos, lo cual es de vital importancia a la hora de estudiar estos tumores y de iniciar el tratamiento de los mismos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hipoxia tisular en los sarcomas osteoblasticos sobre la supervivencia: papel de la expresi\u00f3n proteica de hif-1\u00aa, vegf y del 17b estradiol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hipoxia tisular en los sarcomas osteoblasticos sobre la supervivencia: papel de la expresi\u00f3n proteica de hif-1\u00aa, vegf y del 17b estradiol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Ram\u00edrez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Garc\u00eda Castellano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Regidor Garc\u00eda <\/li>\n<li> Jim\u00e9nez d\u00edaz Juan  Fernando (vocal)<\/li>\n<li> Torres galv\u00e1n Mar\u00eda Jos\u00e9 (vocal)<\/li>\n<li>Francisco Garc\u00eda esteo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Ram\u00edrez S\u00e1nchez Existe un gran paralelismo entre los fen\u00f3menos tumorales \u00f3seos con los fen\u00f3menos de curaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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