{"id":75871,"date":"2018-03-09T23:21:10","date_gmt":"2018-03-09T23:21:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-accion-antioxidante-de-nuevos-farmacos-antiasmaticos-inhibidores-de-fosfodiestersa4-en-cultivos-celulares-de-epitelio-y-musculo-liso-de-va%c2%adas-aereas-humanas\/"},"modified":"2018-03-09T23:21:10","modified_gmt":"2018-03-09T23:21:10","slug":"estudio-de-la-accion-antioxidante-de-nuevos-farmacos-antiasmaticos-inhibidores-de-fosfodiestersa4-en-cultivos-celulares-de-epitelio-y-musculo-liso-de-va%c2%adas-aereas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-accion-antioxidante-de-nuevos-farmacos-antiasmaticos-inhibidores-de-fosfodiestersa4-en-cultivos-celulares-de-epitelio-y-musculo-liso-de-va%c2%adas-aereas-humanas\/","title":{"rendered":"Estudio de la acci\u00f3n antioxidante de nuevos f\u00e1rmacos antiasm\u00e1ticos (inhibidores de fosfodiestersa4) en cultivos  celulares de epitelio y m\u00fasculo liso de v\u00edas a\u00e9reas humanas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luisa Bert\u00f3 Navarro <\/strong><\/h2>\n<p>La investigaci\u00f3n de nuevos f\u00e1rmacos antiasm\u00e1ticos es necesaria por la relevancia de esta patolog\u00eda. En la presente tesis se ha estudiado el mecanismo de la actividad antioxidante de inhibidores de fosfodiesterasa 4 (pde4) y otros f\u00e1rmacos de referencia en c\u00e9lulas epiteliales (beas-2b) y musculares lisas de v\u00edas a\u00e9reas humanas, obteniendo las siguientes conclusiones: el rolipram, un inhibidor pde4, ejerce una protecci\u00f3n, concentraci\u00f3n-dependiente, frente al da\u00f1o celular provocado por la exposici\u00f3n a xantina\/xantina oxidasa y agua oxigenada en c\u00e9lulas epiteliales y musculares lisas de v\u00edas a\u00e9reas humanas. Este efecto citoprotector tambi\u00e9n se observa en otros f\u00e1rmacos considerados como inhibidores relativamente selectivos de fosfodiesterasa 4 como la dembufilina y el ah-21-132, pero no se detect\u00f3 en f\u00e1rmacos inhibidores selectivos de la fosfodiesterasa tipo 3 como el skf94120 y la milrinona. el rolipram y otros inhibidores selectivos de pde4 carecen de actividad antioxidante directa frente a xantina\/xantina oxidasa y agua oxigenada en sistemas libres de c\u00e9lulas. El aumento de la concentraci\u00f3n de amp c\u00edclico y la disminuci\u00f3n del calcio intracelular demostradas en presencia de rolipram, pero no de los inhibidores de otras isoenzimas, sugieren que el efecto citoprotector de los inhibidores pde4 podr\u00eda estar relacionado con la conocida inhibici\u00f3n funcional ejercida por estos f\u00e1rmacos sobre la se\u00f1alizaci\u00f3n intracelular del calcio.  Este efecto antioxidante puede contribuir a la actividad antiasm\u00e1tica de esta nueva categor\u00eda farmacol\u00f3gica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la acci\u00f3n antioxidante de nuevos f\u00e1rmacos antiasm\u00e1ticos (inhibidores de fosfodiestersa4) en cultivos  celulares de epitelio y m\u00fasculo liso de v\u00edas a\u00e9reas humanas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la acci\u00f3n antioxidante de nuevos f\u00e1rmacos antiasm\u00e1ticos (inhibidores de fosfodiestersa4) en cultivos  celulares de epitelio y m\u00fasculo liso de v\u00edas a\u00e9reas humanas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luisa Bert\u00f3 Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Morcillo S\u00e1nchez Esteban J.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Moreno gonzalez <\/li>\n<li>federico Pallard\u00f3 calatayud (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>gustavo Juan  samper (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luisa Bert\u00f3 Navarro La investigaci\u00f3n de nuevos f\u00e1rmacos antiasm\u00e1ticos es necesaria por la relevancia de esta patolog\u00eda. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,483],"tags":[3585,11786,4080,12212,163856,50978],"class_list":["post-75871","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","tag-alfonso-moreno-gonzalez","tag-federico-pallardo-calatayud","tag-francisco-zaragoza-garcia","tag-gustavo-juan-samper","tag-luisa-berto-navarro","tag-morcillo-sanchez-esteban-j"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=75871"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75871\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=75871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=75871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=75871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}