{"id":75888,"date":"2018-03-09T23:21:10","date_gmt":"2018-03-09T23:21:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-la-estructura-tridimensional-de-la-glucogeno-sintasa-de-pyrococcus-abyssi\/"},"modified":"2018-03-09T23:21:10","modified_gmt":"2018-03-09T23:21:10","slug":"determinacion-de-la-estructura-tridimensional-de-la-glucogeno-sintasa-de-pyrococcus-abyssi","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/determinacion-de-la-estructura-tridimensional-de-la-glucogeno-sintasa-de-pyrococcus-abyssi\/","title":{"rendered":"Determinaci\u00f3n de la estructura tridimensional de la gluc\u00f3geno sintasa de pyrococcus abyssi"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Horcajada Garro <\/strong><\/h2>\n<p>Las gluc\u00f3geno y las almid\u00f3n sitasas son glicosiltransferasas que catalizan la transferencia con retenci\u00f3n de la configuraci\u00f3n de residuos glucosilo al extremo no reductor de una cadena creciente del glucano alfa-1,4. Este proceso es central en el metabolismo energ\u00e9tico de la mayor\u00eda de organismos vivos.  en esta tesis hemos descrito la estructura cristalogr\u00e1fica de la gluc\u00f3geno sintasa de pyrococcus abyssi, un enzima que puede usar tanto udp- como adp-glucosa como donadores de glucosilo. A pesar de que la tecnolog\u00eda de las subunidades de este enzima son parecidas a las descritas recientemente para la sintasa bacteriana de agrobacterium tumefaciens, su organizaci\u00f3n molecular presenta diferencias muy considerables. La sintasa de arqueon es homotrim\u00e9rica en el cristal y en soluci\u00f3n, como lo muestran los experimentos de ultracentrifugaci\u00f3n anal\u00edtica y microscop\u00eda electr\u00f3nica. La disposici\u00f3n de las subnidades confiere a la mol\u00e9cula una forma triangular evidente.  la comparaci\u00f3n de la prote\u00edna de arqueon con otras glicosiltransferasas que act\u00faan con retenci\u00f3n de la configuraci\u00f3n nos han permitido identificar los residuos que determinan la especificidad por el donador de glucosilo, y proponer un modelo estructural que permite explicar las bases de la regulaci\u00f3n de las gluc\u00f3geno sintasas eucariotas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de la estructura tridimensional de la gluc\u00f3geno sintasa de pyrococcus abyssi<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de la estructura tridimensional de la gluc\u00f3geno sintasa de pyrococcus abyssi <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Horcajada Garro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Carles Ferrer Artigas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Rubio <\/li>\n<li>antoni Planas (vocal)<\/li>\n<li>pedro Alzari (vocal)<\/li>\n<li>carme Rovira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Horcajada Garro Las gluc\u00f3geno y las almid\u00f3n sitasas son glicosiltransferasas que catalizan la transferencia con retenci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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