{"id":75893,"date":"2018-03-09T23:21:10","date_gmt":"2018-03-09T23:21:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sintesis-y-evaluacion-de-nuevos-agentes-antineoplasicos-basados-en-productos-naturales\/"},"modified":"2018-03-09T23:21:10","modified_gmt":"2018-03-09T23:21:10","slug":"diseno-sintesis-y-evaluacion-de-nuevos-agentes-antineoplasicos-basados-en-productos-naturales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/diseno-sintesis-y-evaluacion-de-nuevos-agentes-antineoplasicos-basados-en-productos-naturales\/","title":{"rendered":"Dise\u00f1o, sintesis y evaluacion de nuevos agentes antineoplasicos basados en productos naturales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Andres Reyes Abad <\/strong><\/h2>\n<p>Se ha llevado a cabo un estudio fitoqu\u00edmico de plumeria pudica jacquin, una planta procedente de la flora venezolana. Este estudio ha conducido al aislamiento y la caracterizaci\u00f3n qu\u00edmica y espectrosc\u00f3pica de diversos ligananos, flavonoides, iridoides y triterpenoides. Sobre la base de los antecedentes de la actividad farmacol\u00f3gica de la podofilotoxina, un ciclolignano encontrado en la planta objeto del estudio, se han preparado diversos derivados de este metabolito mediante su manipulaci\u00f3n estructural en el laboratorio. para la realizaci\u00f3n de estas transformaciones se ha partido de podofilotoxina aislada de podophyllum emodi debido a la peque\u00f1a cantidad del metabolito encontrado en la planta estudiada. Se han preparado distintos compuestos mediante cicloadici\u00f3n de diels-alder de los \u00e1cidos thurif\u00e9rico y epithurif\u00e9rico con cilopentadieno. Adicionalmente se han obtenido diversos pinacoles mediante reacci\u00f3n de mcmurry por acoplamiento de la podofilotoxona con distintos compuestos carbon\u00edlicos. Todos los compuestos, tanto los naturales como los preparados en el laboratorio se sometieron a distintos ensayos de actividad biol\u00f3gica. Muchos de los compuestos semisint\u00e9ticos han mostrado una citotoxicidad mayor que la sustancia de referencia podofilotoxina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, sintesis y evaluacion de nuevos agentes antineoplasicos basados en productos naturales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, sintesis y evaluacion de nuevos agentes antineoplasicos basados en productos naturales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Andres Reyes Abad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Lopez P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julio Gonz\u00e1lez urones <\/li>\n<li>beatriz De pascual-teresa fern\u00e1ndez (vocal)<\/li>\n<li> Rodriguez tudela Juan  Luis (vocal)<\/li>\n<li>carmen Cuevas marchante (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Andres Reyes Abad Se ha llevado a cabo un estudio fitoqu\u00edmico de plumeria pudica jacquin, una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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