{"id":75946,"date":"2018-03-09T23:21:15","date_gmt":"2018-03-09T23:21:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fenota%c2%adpico-de-ratones-transgenicos-con-sobreexpresion-del-receptor-de-glucocorticoides\/"},"modified":"2018-03-09T23:21:15","modified_gmt":"2018-03-09T23:21:15","slug":"estudio-fenota%c2%adpico-de-ratones-transgenicos-con-sobreexpresion-del-receptor-de-glucocorticoides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-fenota%c2%adpico-de-ratones-transgenicos-con-sobreexpresion-del-receptor-de-glucocorticoides\/","title":{"rendered":"Estudio fenot\u00edpico de ratones transg\u00e9nicos con sobreexpresi\u00f3n del receptor de glucocorticoides"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cascallana \u00e1lvarez Jos\u00e9 Luis <\/strong><\/h2>\n<p>En este estudio investigamos los efectos, in vivo, producidos por una ganancia de funci\u00f3n del receptor del glucocorticoides (gr), inducida por la sobreexpresi\u00f3n de este receptor en epitelios estratificados, vehiculada por un promotor espec\u00edfico de tejido. Para ello, caracterizamos el fenotipo de los ratones transg\u00e9nicos generados previamente (k5-gr), que expresan el gr bajo el control del promotor de la queratina k5 bovina.  los ratones k5-gr mostraron un retraso en la diferenciaci\u00f3n durante la morfog\u00e9nesis epid\u00e9rmica, un menor n\u00famero y displasia de los fol\u00edculos piloso, una displasia y reducido n\u00famero de gl\u00e1ndulas ectod\u00e9rmicas, ecrinas y holocrinas, debida en ocasiones a la agenesia de las mismas, un retraso en la diferenciaci\u00f3n malformaciones caracter\u00edsticas de las displasias ectod\u00e9rmicas humanas como son la aplasia cutis cong\u00e9nita, la piel fina, la disminuci\u00f3n del n\u00famero de fol\u00edculos pilosos, menor sudoraci\u00f3n por ausencia\/disminuci\u00f3n de gl\u00e1nculas sudor\u00edparas, la ausencia de gl\u00e1nculas de meibomio, la oligodoncia y el retaso en la odontog\u00e9nesis, por lo que los ratones transg\u00e9nicos k5-gr constituyen un nuevo modelo para el estudio de estos s\u00edndromes. As\u00ed mismo, la hendidura del paladar secundario, observada en el 13,5% de los ratones transg\u00e9nicos k5-gr supone un nuevo modelo animal para el estudio del paladar hendido humano.  los ratones con mayor expresi\u00f3n fenot\u00edpica adem\u00e1s de la falta de desarrollo de uno o dos p\u00e1rpados mostraron malformaciones graves que determinaban su muerte perinatal como son la acrania con excencefalia, la gastroschisis y la hendidura palatina. Estas malformaciones graves no aparecen en los fenotipos de los otros modelos murinos d eed descritas hasta el momento, en los cuales existen disfunciones de la v\u00eda nf-kb. Para confirmar que el fenotipo de los transg\u00e9nicos k5-gr se debe, espec\u00edficamente, a la sobreexpresi\u00f3n de gr, hemos realizado experimentos consistentes en la adminis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fenot\u00edpico de ratones transg\u00e9nicos con sobreexpresi\u00f3n del receptor de glucocorticoides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fenot\u00edpico de ratones transg\u00e9nicos con sobreexpresi\u00f3n del receptor de glucocorticoides <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cascallana \u00e1lvarez Jos\u00e9 Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bravo Moral Ana M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor manuel Arce vazquez <\/li>\n<li> Paramio gonz\u00e1lez Jes\u00fas m. (vocal)<\/li>\n<li>\u00e1ngel Ram\u00edrez merino (vocal)<\/li>\n<li> Pinazo dur\u00e1n m. dolores (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cascallana \u00e1lvarez Jos\u00e9 Luis En este estudio investigamos los efectos, in vivo, producidos por una ganancia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,156,977],"tags":[7257,163987,163986,152521,163988,138319],"class_list":["post-75946","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-patologia","category-santiago-de-compostela","tag-angel-ramirez-merino","tag-bravo-moral-ana-m","tag-cascallana-alvarez-jose-luis","tag-paramio-gonzalez-jesus-m","tag-pinazo-duran-m-dolores","tag-victor-manuel-arce-vazquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=75946"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/75946\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=75946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=75946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=75946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}