{"id":75982,"date":"2018-03-09T23:21:19","date_gmt":"2018-03-09T23:21:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-mecanismo-de-toxicidad-de-los-acidos-grasos-poliinsaturados-en-linfomas-y-linfocitos-humanos\/"},"modified":"2018-03-09T23:21:19","modified_gmt":"2018-03-09T23:21:19","slug":"estudio-del-mecanismo-de-toxicidad-de-los-acidos-grasos-poliinsaturados-en-linfomas-y-linfocitos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cultivo-celular\/estudio-del-mecanismo-de-toxicidad-de-los-acidos-grasos-poliinsaturados-en-linfomas-y-linfocitos-humanos\/","title":{"rendered":"Estudio del mecanismo de toxicidad de los acidos grasos poliinsaturados en linfomas y linfocitos humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Teresa Desportes Bielsa <\/strong><\/h2>\n<p>En este trabajo se ha profundizado en el estudio del mecanismo de toxicidad de los \u00e1cidos grasos polisaturados en c\u00e9lulas linfoides humanas tanto normales como tumorales, poniendo especial hincapi\u00e9 en el papel de la peroxidaci\u00f3n lip\u00eddica como causante de esta toxicidad. Se ha ampliado el n\u00famero y tipo de antioxidantes analizados (\u00c2\u00bf-tocoferol, selenio, \u00e1cido lipoico, n-acetilcisteina, bht,bha) y se ha investigado el posible papel de tres enzimas de detoxificaci\u00f3n dependientes del glutation (glutation- s-transferasa (gst), glutation reductasa (gr) y glutation peroxidasa (gpo), en la toxicidad de estos \u00e1cidos grasos. En particular se han estudiado con mayor atenci\u00f3n los \u00e1cidos grasos docosahexenoico( 22:6 n-3, el m\u00e1s t\u00f3xico) y \u00c2\u00bf-linol\u00e9nico (18:3 n-6, anormalmente t\u00f3xico para su n\u00famro de dobles enlaces), as\u00ed como los involucrados en la ruta alternativa de s\u00edntesis de \u00e1cidos grasos descubierta en la leucemia mieloide humana k562, se llev\u00f3 a cabo tambi\u00e9n la selecci\u00f3n de c\u00e9lulas resistentes a distintos \u00e1cidos grasos, y se realizaron estudios comparativos de las actividades enzim\u00e1ticas de detoxificaci\u00f3n y de composici\u00f3n lip\u00eddica de estas c\u00e9lulas con las correspondientes de las c\u00e9lulas sensibles. Por \u00faltimo, se llevo a cabo un estudio sobre la influencia de varios \u00e1cidos grasos poliinsaturados en la diferenciaci\u00f3n de la leucemia mieloide k562.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del mecanismo de toxicidad de los acidos grasos poliinsaturados en linfomas y linfocitos humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del mecanismo de toxicidad de los acidos grasos poliinsaturados en linfomas y linfocitos humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Teresa Desportes Bielsa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Naval Iraberri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andres Pi\u00f1ero anton <\/li>\n<li>Jorge Laborda fernandez (vocal)<\/li>\n<li>Miguel Calvo rebollar (vocal)<\/li>\n<li>hans kristian Lorenzo gracia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Teresa Desportes Bielsa En este trabajo se ha profundizado en el estudio del mecanismo de toxicidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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