{"id":75988,"date":"2018-03-09T23:21:19","date_gmt":"2018-03-09T23:21:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-aplicacion-de-moleculas-con-actividad-bloqueante-de-semaforinas\/"},"modified":"2018-03-09T23:21:19","modified_gmt":"2018-03-09T23:21:19","slug":"desarrollo-y-aplicacion-de-moleculas-con-actividad-bloqueante-de-semaforinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/desarrollo-y-aplicacion-de-moleculas-con-actividad-bloqueante-de-semaforinas\/","title":{"rendered":"Desarrollo y aplicaci\u00f3n de moleculas con actividad bloqueante de semaforinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Nontolio Del Olmo Marisol <\/strong><\/h2>\n<p>Nuestros datos demuestran que un peptoide, sichi, es capaz de inhibir espec\u00edficamente la quimorepulsi\u00f3n producida por semaforina 3a, exogena yendogenamente, en el crecimiento de axoles hipocampicos en distintos modelos. Este bloqueo de la quimiorepulsi\u00f3n se debe principalmente a una prevenci\u00f3n del colapso del cono axonal, y es dasis-dependiente. Act\u00faa a nivel da ligando-receptor y es capaz de producir regeneraci\u00f3n axonal de la v\u00eda perforante tras una lesi\u00f3n, adem\u00e1s de aumentar la supervivencia neuronal de c\u00e9lulas de hipocampo, cerebelo y ganglio nodoso.  por otro lado, nuestros resultados indican la implicaci\u00f3n del calcio intracelular en la se\u00f1alizaci\u00f3n mediada por semafarina 3a. Mediante explantes de hipocampo confrontados a semafarina 3a tratados con quelantes de calcio, o inhibidores de calcineurina y calmoducinkinasa ii se observ\u00f3 una implicaci\u00f3n de calcineurina en &#8212; de se\u00f1alizaci\u00f3n de semaforina 3a. Tambi\u00e9n observamos como semaforfina 3a y calcineurina pero no calmodulinkinasa ii controlan la translocaci\u00f3n nuclear del factor de transcripci\u00f3n nfatc4.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y aplicaci\u00f3n de moleculas con actividad bloqueante de semaforinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y aplicaci\u00f3n de moleculas con actividad bloqueante de semaforinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Nontolio Del Olmo Marisol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Soriano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Messeguer peypoch <\/li>\n<li>enric Verd\u00fa (vocal)<\/li>\n<li>anna Planas (vocal)<\/li>\n<li>joan Blasi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nontolio Del Olmo Marisol Nuestros datos demuestran que un peptoide, sichi, es capaz de inhibir espec\u00edficamente la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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