{"id":76064,"date":"2018-03-09T23:21:23","date_gmt":"2018-03-09T23:21:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonaje-y-caracterizacion-funcional-de-mouse-neuron-navigator-1-una-nueva-proteina-asociada-a-los-microtubulos-implicada-en-la-migracion-neuronal\/"},"modified":"2018-03-09T23:21:23","modified_gmt":"2018-03-09T23:21:23","slug":"clonaje-y-caracterizacion-funcional-de-mouse-neuron-navigator-1-una-nueva-proteina-asociada-a-los-microtubulos-implicada-en-la-migracion-neuronal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/clonaje-y-caracterizacion-funcional-de-mouse-neuron-navigator-1-una-nueva-proteina-asociada-a-los-microtubulos-implicada-en-la-migracion-neuronal\/","title":{"rendered":"Clonaje y caracterizaci\u00f3n funcional de mouse neuron navigator-1, una nueva proteina asociada a los microtubulos implicada en la migraci\u00f3n neuronal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Lopez M. Jos\u00e9 <\/strong><\/h2>\n<p>La migraci\u00f3n celular es un evento importante en m\u00faltiples aspectos del desarrollo de los seres vivos, sin embargo, los mecanismos moleculares que gu\u00edan esta migraci\u00f3n est\u00e1n lejos de conocerse. La identificaci\u00f3n de los genes implicados en estos procesos en caenorhabditis elegans y drosophila, y el estudio de sus hom\u00f3logos en mam\u00edferos han revelado la conservaci\u00f3n a trav\u00e9s de la evoluci\u00f3n de las mol\u00e9culas de gu\u00eda de transducci\u00f3n de las se\u00f1ales.  el gen unc-53 de caenorhabditis elegans es uno de estos genes con un papel clave en la migraci\u00f3n antero-posterior de un conjunto de c\u00e9lulas migratorias y de sus axones. En este trabajo describimos el clonaje y primera caracterizaci\u00f3n funcional de su hom\u00f3logo murino, mouse neuron navigator 1(mnav1).Mnav1 es un nuevo gen preferentemente expresado en el sistema nervioso (sn) y en el coraz\u00f3n. La expresi\u00f3n de mnav1 en el sn est\u00e1 restringida a estadios embrionarios y etapas postnatales. Durante el desarrollo del sn est\u00e1 restringida a estadios embrionarios y etapas postnatales. Durante el desarrollo del sn, est\u00e1 limitada a neuronas pstmit\u00f3ticas postmigratorias y algunas v\u00edas migratorias. Egfp-mnav1 se asocia con los microt\u00fabulos (mts), una caracter\u00edstica \u00fanica que no ha sido previamente descrita para otros miembros de la familia. adem\u00e1s, esta asociaci\u00f3n es especialmente importante en los extremos + de los mts y est\u00e1 mediada por un nuevo dominio. En las neuronas, egfp-nnav1 est\u00e1 localizada en los conos de crecimiento, donde v\u00edas de se\u00f1alizaci\u00f3n celular son activadas por mol\u00e9culas de gu\u00eda y que convengen en el citoesqueleto de los conos de crecimiento.  finalmente, el silenciamiento de su expresi\u00f3n end\u00f3gena provoca la p\u00e9rdida del direccionamiento de algunas neuronas en migraci\u00f3n sugiriendo la implicaci\u00f3n mnav1 en los mecanismos en los cuales los leading processes encuentran la ruta hasta su diana apropiada a trav\u00e9s del embri\u00f3n en desarrollo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonaje y caracterizaci\u00f3n funcional de mouse neuron navigator-1, una nueva proteina asociada a los microtubulos implicada en la migraci\u00f3n neuronal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonaje y caracterizaci\u00f3n funcional de mouse neuron navigator-1, una nueva proteina asociada a los microtubulos implicada en la migraci\u00f3n neuronal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Lopez M. Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/07\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Martinez Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Soriano Garc\u00eda <\/li>\n<li>elisa Marti gorostiza (vocal)<\/li>\n<li>diego Haro bautista (vocal)<\/li>\n<li>estanis Navarro gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Lopez M. Jos\u00e9 La migraci\u00f3n celular es un evento importante en m\u00faltiples aspectos del desarrollo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,35],"tags":[34232,24803,10152,164212,7883,2966],"class_list":["post-76064","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-de-la-vida","tag-diego-haro-bautista","tag-eduardo-soriano-garcia","tag-elisa-marti-gorostiza","tag-estanis-navarro-gomez","tag-jose-antonio-Martinez-izquierdo","tag-Martinez-lopez-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76064"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76064\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}