{"id":76101,"date":"2005-07-09T00:00:00","date_gmt":"2005-07-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-degradoma-humano-definicion-del-grupo-de-las-poliserasas-e-identificacion-de-nuevas-metaloproteasas-de-la-familia-adamts\/"},"modified":"2005-07-09T00:00:00","modified_gmt":"2005-07-09T00:00:00","slug":"analisis-del-degradoma-humano-definicion-del-grupo-de-las-poliserasas-e-identificacion-de-nuevas-metaloproteasas-de-la-familia-adamts","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-del-degradoma-humano-definicion-del-grupo-de-las-poliserasas-e-identificacion-de-nuevas-metaloproteasas-de-la-familia-adamts\/","title":{"rendered":"Analisis del degradoma humano definicion del grupo de las poliserasas e identificacion de nuevas  metaloproteasas de la familia adamts"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Llamazares Prada <\/strong><\/h2>\n<p>El degradoma se ha definido como el conjunto de proteasas que se producen en una circunstancia determinada por una c\u00e9lula, un tejido o un organismo completo. En humanos, las proteasas representan el 2% del genoma, desempe\u00f1ando un papel fundamental en la regulaci\u00f3n de multitud de rutas de las que dependen la vida y la muerte de las c\u00e9lulas. De este modo, los enzimas proteol\u00edticos participan en procesos fisiol\u00f3gicos esenciales tales como la fertilizaci\u00f3n, el desarrollo embrionario, la formaci\u00f3n y desarrollo de los huesos, la cicatrizaci\u00f3n de heridas, la presentaci\u00f3n antig\u00e9nica y el desarrollo neuronal. en la presente tesis doctoral se ha contribuido a la caracterizaci\u00f3n del degradoma humano mediante la identificaci\u00f3n de diez nuevas proteasas. Ocho de ellas,  denominadas adamts13, -14, -15, -16, -17, -18, -19 y -20, pertenecen a la familia de metaloproteasas de la matriz extracelular con dominios disintegrina y trombospondina (adamts). Los genes de estos enzimas se expresan principalmente en tejidos fetales pudiendo intervenir en el desarrollo embrionario. Algunas de las adamtss descritas podr\u00edan estar implicadas en diversas etapas de la progresi\u00f3n tumoral al sobreexpresarse en distintos tipos de tumores humanos. Adem\u00e1s, durante el transcurso del presente trabajo, se ha profundizado en el an\u00e1lisis funcional de una de estas nuevas adamtss, la denominada adamts20. En este sentido, se ha generado una prote\u00edna recombinante que porta el dominio catal\u00edtico de la adamts20 y se ha ensayado su actividad frente a sustratos fluorog\u00e9nicos de metaloproteasas. Estos estudios han permitido demostrar que esta nueva proteasa es un enzima catal\u00edticamente activo. El estudio funcional de las adamtss se ha extendido en esta tesis con el trabajo dirigido a la generaci\u00f3n de ratones deficientes en adamts12, otro componente de esta familia de metaloproteasas, previamente descrito en nuestro laboratorio y de notable inter\u00e9s por su sobreexpresi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis del degradoma humano definicion del grupo de las poliserasas e identificacion de nuevas  metaloproteasas de la familia adamts<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis del degradoma humano definicion del grupo de las poliserasas e identificacion de nuevas  metaloproteasas de la familia adamts <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Llamazares Prada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Lopez Otin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  antonia Lizarbe  iracheta <\/li>\n<li>eulalia Valle garay (vocal)<\/li>\n<li>xavier Gomis ruth (vocal)<\/li>\n<li>Jes\u00fas Fernandez aparicio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Llamazares Prada El degradoma se ha definido como el conjunto de proteasas que se producen en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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