{"id":76118,"date":"2005-09-09T00:00:00","date_gmt":"2005-09-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-clinica-de-la-enfermedad-coronaria-precoz-prevencion-secundaria-y-bases-geneticas\/"},"modified":"2005-09-09T00:00:00","modified_gmt":"2005-09-09T00:00:00","slug":"evolucion-clinica-de-la-enfermedad-coronaria-precoz-prevencion-secundaria-y-bases-geneticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evolucion-clinica-de-la-enfermedad-coronaria-precoz-prevencion-secundaria-y-bases-geneticas\/","title":{"rendered":"Evolucion clinica de la enfermedad coronaria precoz. prevencion secundaria y bases geneticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Martin Fernandez <\/strong><\/h2>\n<p>La enfermedad coronaria como principal causa de muerte en los pa\u00edses desarrollados alcanza una importancia capital dentro de la investigaci\u00f3n biom\u00e9dica. El mejor conocimiento de la fisiopatolog\u00eda de la enfermedad cardiovascular ha permitido la integraci\u00f3n de los m\u00faltiples factores que intervienen en la g\u00e9nesis de estos procesos fisiol\u00f3gicos, hemodin\u00e1micos, ambientales, hormonales y gen\u00e9ticos. El manejo actual de la enfermedad coronaria asocia armas terap\u00e9uticas cada vez  m\u00e1s eficaces y un concepto fundamental: la prevenci\u00f3n secundaria, que mediante la modificaci\u00f3n de h\u00e1bitos del paciente y el empleo adecuado de f\u00e1rmacos busca frenar la evoluci\u00f3n de la enfermedad y  mejorar la calidad de vida.  se analiza una muestra de 168 pacientes varones ingresados en la unidad coronaria con diagn\u00f3stico de infarto agudo de miocardio, realiz\u00e1ndose un estudio prospectivo y observacional. Se analizan los factores de riesgo presentes al ingreso, la evoluci\u00f3n cl\u00ednica y el nivel de prevenci\u00f3n secundaria alcanzado, con un seguimiento medio de 72 \u00c2\u00b1 35 meses . Asimismo, se estudian factores pron\u00f3sticos predictores tanto metab\u00f3licos como gen\u00e9ticos.  Todos los pacientes han sido genotipados para los genes: eca, enos, apoa1 y abca1, compar\u00e1ndose la distribuci\u00f3n genot\u00edpica de la muestra con un grupo de pacientes con coronarias normales. En los resultados, se ha obtenido una evoluci\u00f3n cl\u00ednica desfavorable en un 41 % de los pacientes, con un deficiente cumplimiento de los niveles de prevenci\u00f3n secundaria. Los pacientes que al final del seguimiento presentaban tres o m\u00e1s criterios de s\u00edndrome metab\u00f3lico desarrollaron una evoluci\u00f3n desfavorable. Los pacientes homocigotos cc para el gen abca1 presentaron una peor evoluci\u00f3n cl\u00ednica, en cambio, la homocigosis dd para el gen de la eca se relacion\u00f3 con mayor progresi\u00f3n angiogr\u00e1fica de la enfermedad coronaria. En el an\u00e1lisis multivariante, los niveles de lp (a) superiores a 10mg\/dl y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evolucion clinica de la enfermedad coronaria precoz. prevencion secundaria y bases geneticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evolucion clinica de la enfermedad coronaria precoz. prevencion secundaria y bases geneticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Martin Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez Reguero Jos\u00e9 Julian<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas castrillo Jos\u00e9 manuel <\/li>\n<li> Berrazueta fernandez Jos\u00e9 ramon (vocal)<\/li>\n<li> Sagastagoitia gorostiza Jos\u00e9 domingo (vocal)<\/li>\n<li>Francisco Gosalbez jorda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Martin Fernandez La enfermedad coronaria como principal causa de muerte en los pa\u00edses desarrollados alcanza una 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