{"id":76140,"date":"2005-12-09T00:00:00","date_gmt":"2005-12-09T00:00:00","guid":{"rendered":""},"modified":"2005-12-09T00:00:00","modified_gmt":"2005-12-09T00:00:00","slug":"ensayo-cla%c2%adnico-randomizado-paralelo-fase-iv-de-eficacia-de-levobupivacaa%c2%adna-mas-fentanilo-1-ug-ml-controlado-con-bupivacaa%c2%adna-mas-fentanilo-1-ug-ml-y-ropivacaa%c2%adna-mas-fentani","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/ensayo-cla%c2%adnico-randomizado-paralelo-fase-iv-de-eficacia-de-levobupivacaa%c2%adna-mas-fentanilo-1-ug-ml-controlado-con-bupivacaa%c2%adna-mas-fentanilo-1-ug-ml-y-ropivacaa%c2%adna-mas-fentani\/","title":{"rendered":"Ensayo cl\u00ednico randomizado, paralelo, fase iv, de eficacia de levobupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. controlado con bupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. y ropivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. en la analgesia del parto."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ati\u00e9nza G\u00f3mez  M. Carmen <\/strong><\/h2>\n<p>Hip\u00f3tesis de trabajo: evaluaci\u00f3n de la eficacia analg\u00e9sica de un nuevo anest\u00e9sico local por v\u00eda epidural, la levobupivaca\u00edna, en relaci\u00f3n a otros anest\u00e9sicos locales (bupivaca\u00edna y ropivaca\u00edna) para el control del dolor del primer estadio del  trabajo del parto.  objetivo:  evaluar la no-inferioridad en t\u00e9rminos de efecto analg\u00e9sico de levobupivaca\u00edna versus bupivaca\u00edna y ropivaca\u00edna. Se  intentar\u00e1 demostrar que la analgesia obtenida con levobupivaca\u00edna 0,125% m\u00e1s 1 g\/ml fentanilo, administrado en perfusi\u00f3n continua en el primer estadio del trabajo del parto, es no-inferior a la obtenida con dosis equianalg\u00e9sicas de los otros dos anest\u00e9sicos locales: bupivaca\u00edna 0,125% m\u00e1s fentanilo 1 g\/ml  y  ropivaca\u00edna 0,2% m\u00e1s fentanilo 1 g\/ml. Objetivos secundarios: dosis inicial (cantidad de anest\u00e9sico local requerido, tiempo necesario para la instauraci\u00f3n de la analgesia); consumo de anest\u00e9sico local durante la perfusi\u00f3n continua; bloqueo motor y sensitivo;  estabilidad hemodin\u00e1mica materna, efectos adversos y satisfacci\u00f3n materna; repercusi\u00f3n sobre la din\u00e1mica del parto y  estado cl\u00ednico del reci\u00e9n nacido.  material y m\u00e9todo: tras obtener la aprobaci\u00f3n del comit\u00e9 de \u00e9tica, se incluyen 102 pacientes (tras firmar consentimiento informado) en el ensayo cl\u00ednico, doble ciego de no-inferioridad. Criterios: dilataci\u00f3n cervical   4cm, prim\u00edparas ,asa i &#8211; ii,  feto   37 semanas, \u00fanico , presentaci\u00f3n cef\u00e1lica. Se distribuyen aleatoriamente en 3 grupos  recibiendo perfusi\u00f3n continua del anest\u00e9sico asignado (8 ml\/h). En cualquier momento del periodo de dilataci\u00f3n  en que aparec\u00eda un eva   4 (analgesia inadecuada) se administraba un  bolus de analgesia de rescate: 8ml del anest\u00e9sico local en estudio. La variable principal de valoraci\u00f3n: comparaci\u00f3n en la diferencia de dolor respecto al valor basal entre los tres  grupos mediante la eva (de 0 a 10 cm) a los 60 minutos. Si la estimaci\u00f3n de la diferencia en las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ensayo cl\u00ednico randomizado, paralelo, fase iv, de eficacia de levobupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. controlado con bupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. y ropivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. en la analgesia del parto.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ensayo cl\u00ednico randomizado, paralelo, fase iv, de eficacia de levobupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. controlado con bupivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. y ropivaca\u00edna m\u00e1s fentanilo 1 ug\/ml. en la analgesia del parto. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ati\u00e9nza G\u00f3mez  M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Palanca San Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Tortajada mart\u00ednez <\/li>\n<li>raimundo Carlos garcia (vocal)<\/li>\n<li>julio Cortijo gimeno (vocal)<\/li>\n<li>clemente Muriel villoria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ati\u00e9nza G\u00f3mez M. Carmen Hip\u00f3tesis de trabajo: evaluaci\u00f3n de la eficacia analg\u00e9sica de un nuevo anest\u00e9sico local [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1569,9,141],"tags":[164355,9871,8550,12191,8377,3583],"class_list":["post-76140","post","type-post","status-publish","format-standard","hentry","category-anestesiologia-quirurgica","category-ciencias-medicas","category-cirugia","tag-atienza-gomez-m-carmen","tag-clemente-muriel-villoria","tag-jose-maria-palanca-san-francisco","tag-julio-cortijo-gimeno","tag-miguel-tortajada-Martinez","tag-raimundo-carlos-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=76140"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/76140\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=76140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=76140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=76140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}