{"id":76149,"date":"2018-03-09T23:21:31","date_gmt":"2018-03-09T23:21:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-tolerancia-de-nuevos-sistemas-de-administracion-intraocular-preparados-a-partir-de-pola%c2%admeros-bioelasticos\/"},"modified":"2018-03-09T23:21:31","modified_gmt":"2018-03-09T23:21:31","slug":"caracterizacion-y-tolerancia-de-nuevos-sistemas-de-administracion-intraocular-preparados-a-partir-de-pola%c2%admeros-bioelasticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-y-tolerancia-de-nuevos-sistemas-de-administracion-intraocular-preparados-a-partir-de-pola%c2%admeros-bioelasticos\/","title":{"rendered":"Caracterizaci\u00f3n y tolerancia de nuevos sistemas de administraci\u00f3n intraocular preparados a partir de pol\u00edmeros bioel\u00e1sticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rinc\u00f3n Alarc\u00f3n Adriana Carolina <\/strong><\/h2>\n<p>El dise\u00f1o de nuevos sistemas terap\u00e9uticos de administraci\u00f3n intraocular ha adquirido gran inter\u00e9s en los \u00faltimos a\u00f1os, al ser cada vez m\u00e1s las patolog\u00edas que afectan al segmento posterior del ojo y que comprometen la visi\u00f3n en un elevado porcentaje de pacientes. Resulta importante, en este campo, la introducci\u00f3n de nuevos biomateriales que, manteniendo su biocompatibilidad, sean capaces de incorporar y ceder adecuadamente la sustancia activa. El objetivo de este trabajo ha sido la evaluaci\u00f3n del poli (valina-prolina-alanina-valina-glicina) [vpavg], pol\u00edmero perteneciente a una novedosa familia de materiales bioel\u00e1sticos derivados de la elastina, como formador de sistemas de cesi\u00f3n controlada para la v\u00eda intraocular. se obtuvieron con este pol\u00edmero agregados de tama\u00f1o variable en funci\u00f3n a la concentraci\u00f3n del poli (vpavg) presente en la formulaci\u00f3n. La tasa de encapsulaci\u00f3n obtenida para el fosfato de dexamentasona disminuye a media que aumenta la concentraci\u00f3n de pol\u00edmero. La cesi\u00f3n inicial de f\u00e1rmaco result\u00f3 superior al 64% y a partir del tercer d\u00eda de ensayo, este proceso se ralentiz\u00f3 cedi\u00e9ndose, al cabo de 42 d\u00edas, entre un 94 y un 97% de la cantidad de sustancia activa incorporada. En la evaluaci\u00f3n de su tolerancia \u00abin vitro\u00bb, se observ\u00f3 como la respiraci\u00f3n celular no se vio significativamente afectada por la concentraci\u00f3n del pol\u00edmero. Por v\u00eda subcut\u00e1nea, las part\u00edculas de este biomaterial demostraron una excelente tolerancia al no inducir inflamaci\u00f3n en la pata de ratas. No obstante, cuando se llev\u00f3 a cabo su administraci\u00f3n intravitrea se produjo un desprendimiento traccional de la retina, por lo que resultaron no id\u00f3neas para se empleadas por esta v\u00eda. Finalmente se evalu\u00f3 el impacto de la radiaci\u00f3n gamma sobre el biomaterial y las formulaciones, determin\u00e1ndose la susceptibilidad de ambos a este tipo de radiaciones como m\u00e9todo de esterilizaci\u00f3n, por lo que, se plante\u00f3 recurrirse a otr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n y tolerancia de nuevos sistemas de administraci\u00f3n intraocular preparados a partir de pol\u00edmeros bioel\u00e1sticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n y tolerancia de nuevos sistemas de administraci\u00f3n intraocular preparados a partir de pol\u00edmeros bioel\u00e1sticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rinc\u00f3n Alarc\u00f3n Adriana Carolina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rocio Herrero Vanrell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Del castillo garcia <\/li>\n<li> Luisa jimenez castellanos Mar\u00eda (vocal)<\/li>\n<li>angel Concheiro nine (vocal)<\/li>\n<li>esther Sanchez sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rinc\u00f3n Alarc\u00f3n Adriana Carolina El dise\u00f1o de nuevos sistemas terap\u00e9uticos de administraci\u00f3n intraocular ha adquirido gran inter\u00e9s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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