{"id":76187,"date":"2018-03-09T23:21:31","date_gmt":"2018-03-09T23:21:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-agonistas-y-antiagonistas-de-los-receptores-serotoninergicos-5-het1a-en-la-esclerosis-multiple\/"},"modified":"2018-03-09T23:21:31","modified_gmt":"2018-03-09T23:21:31","slug":"efecto-de-agonistas-y-antiagonistas-de-los-receptores-serotoninergicos-5-het1a-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-agonistas-y-antiagonistas-de-los-receptores-serotoninergicos-5-het1a-en-la-esclerosis-multiple\/","title":{"rendered":"Efecto de agonistas y antiagonistas de los receptores serotoninergicos 5-het1a en la esclerosis multiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Argibay Vazquez <\/strong><\/h2>\n<p>La encefalitis al\u00e9rgica experimental (eae) es una enfermedad inflamatoria del sistema nervioso central mediada por c\u00e9lulas t que ha sido adoptada como modelo animal de esclerosis m\u00faltiple. En las ratas de lewis y en los ratones cb57l\/6, la prote\u00edna b\u00e1sica (pbm) y la glicoprote\u00edna oligodendroc\u00edtica de la mielina (gom), respectivamente, emulsionadas en el adyuvante completo de freund (acf), originan una eae caracterizada como una enfermedad monof\u00e1sica aguda de la que los animales se recuperan totalmente. En nuestro experimento diario (desde el primer d\u00eda de la inoculaci\u00f3n de la pbm-acf y la gom-acg) con el agonista de los receptores serotonin\u00e9rgicos 1a (r(+)-8-oh-dpta) ocasionaba un incremento dosis-dependiente en los signos histol\u00f3gicos y neurol\u00f3gicos en los animales inducidos que presentaban eae. El efecto del r(+)-8-oh-dpat se pod\u00eda reducir mediante la administraci\u00f3n simult\u00e1nea del antagonista de los receptores serotonin\u00e9rgicos 5-ht1a (way 100635) en el momento m\u00e1s \u00e1lgido de la enfermedad aguda. Adem\u00e1s, el way 100635 a partir de la inoculaci\u00f3n, da como resultado una demora en la aparici\u00f3n de las primeras manifestaciones cl\u00ednicas, una enfermedad m\u00e1s leve y una regresi\u00f3n m\u00e1s temprana de los signos neurol\u00f3gicos conjuntamente con una disminuci\u00f3n en la inflamaci\u00f3n del snc. Por otra parte, el agonista de los receptores serotonin\u00e9rgicos 5-ht1a aumenta los niveles de corticosterona plasm\u00e1tica, incrementa de forma dosis-dependiente la respuesta proliferativa de linfocitos t espl\u00e9nicos sensibilizados con gom35-55, lo que constituye un indicador de reactividad, aumenta la producci\u00f3n de las citocinas proinflamatorias (th1)  il-2, ifn-gamma y tnf alfa, mientras que disminuye la s\u00edntesis de citocinas antiinflamatorias, il-4 y tgf-beta, e tambi\u00e9n, eleva los niveles de anticuerpos espec\u00edficos tanto frente a gom35-55 como a rgom. Dado que los receptores 5-ht1a parecen estar implicados en funciones inmunitarias relacionad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de agonistas y antiagonistas de los receptores serotoninergicos 5-het1a en la esclerosis multiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de agonistas y antiagonistas de los receptores serotoninergicos 5-het1a en la esclerosis multiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Argibay Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Freire Garabal N\u00fa\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Orallo cambeiro <\/li>\n<li>Francisco Javier De toro santos (vocal)<\/li>\n<li>\u00c1lvaro Ruibal morell (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas Sanz ferrando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Argibay Vazquez La encefalitis al\u00e9rgica experimental (eae) es una enfermedad inflamatoria del sistema nervioso central mediada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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