{"id":76202,"date":"2018-03-09T23:21:35","date_gmt":"2018-03-09T23:21:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-del-efecto-del-acido-folico-acido-levofolinico-y-acido-folico-mas-vitamina-b12-sobre-los-niveles-de-homocisteina-plasmatica-en-mujeres-sanas-en-edad-reproductiva\/"},"modified":"2018-03-09T23:21:35","modified_gmt":"2018-03-09T23:21:35","slug":"estudio-comparativo-del-efecto-del-acido-folico-acido-levofolinico-y-acido-folico-mas-vitamina-b12-sobre-los-niveles-de-homocisteina-plasmatica-en-mujeres-sanas-en-edad-reproductiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/estudio-comparativo-del-efecto-del-acido-folico-acido-levofolinico-y-acido-folico-mas-vitamina-b12-sobre-los-niveles-de-homocisteina-plasmatica-en-mujeres-sanas-en-edad-reproductiva\/","title":{"rendered":"Estudio comparativo del efecto del acido folico, acido levofolinico y acido folico m\u00e1s vitamina b12 sobre los niveles de homocisteina plasm\u00e1tica en mujeres sanas en edad reproductiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amelia Valladolid Urdangaray <\/strong><\/h2>\n<p>Una concentraci\u00f3n elevada de homociste\u00edna plasm\u00e1tica es un factor de riesgo paralos defectos del tubo neural, aborto de repetici\u00f3n y desprendimiento de placenta. Fuera del \u00e1mbito perinatal est\u00e1 relacionado con problemas vasculares, especialmente aterosclerosis y trombosis. Los folatos a dosis farmacol\u00f3gicas, disminuyen la homociste\u00edna plasm\u00e1tica. este estudio se ha dise\u00f1ado para comparar el efecto de la toma oral de \u00e1cido f\u00f3lico, \u00e1cido levofol\u00ednico y \u00e1cido f\u00f3lico m\u00e1s vitamina b12 sobre la homociste\u00edna plasmatica en mujeres j\u00f3venes en edad reproductiva. Es un estudio aleatorizado y controlado, realizado con 60 mujeres sanas, no gestantes, de edad comprendida entre 18 y 40 a\u00f1os. Las mujeres fueron seleccionadas de forma aleatoria para recibir durante 30 d\u00edas uno de los siguientes tratamientos: 5 mg\/d\u00eda de \u00e1cido f\u00f3lico (n=20), 5 mg\/d\u00eda de \u00e1cido levofol\u00ednico (n=20) o 400 ug de \u00e1cido f\u00f3lico m\u00e1s 2ug de vitamina b12 (n=20). Todas las pacientes continuaron con su dieta habitual. se realizaron determinaciones sangu\u00edneas de homociste\u00edna plasm\u00e1tica, folatos s\u00e9ricos y folatos intraeritrocitarios en los d\u00edas 0 (antes del inicio del tratamiento), +2, +5, +10, +30, +60 y +90. la homociste\u00edna plasm\u00e1tica se determin\u00f3 por inmunoensayo de polarizaci\u00f3n fluorescente, mientras que los folatos s\u00e9ricos y los intraeritrocitarios se determinaron mediante inmunoensayo de quimioluminiscencia. Par el estudio estad\u00edstico se emplearon los test de kolmogorov, de la t de student, anova y de bonferroni. los resultados sugieren que la suplementaci\u00f3n con 5 mg\/d\u00eda de \u00e1cido levofol\u00ednico induce un descenso m\u00e1s r\u00e1pido e intenso de la homociste\u00edna plasm\u00e1tica total que las mismas dosis de \u00e1cido f\u00f3lico o que la asociaci\u00f3n del \u00e1cido f\u00f3lico m\u00e1s vitamina b12. Esta diferencia es significativa ya desde el quinto d\u00eda de tratmiento. Adem\u00e1s la duraci\u00f3n del efecto es superior a la de los otros compuestos analizados, manteniendo los niveles de homociste\u00edn<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo del efecto del acido folico, acido levofolinico y acido folico m\u00e1s vitamina b12 sobre los niveles de homocisteina plasm\u00e1tica en mujeres sanas en edad reproductiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo del efecto del acido folico, acido levofolinico y acido folico m\u00e1s vitamina b12 sobre los niveles de homocisteina plasm\u00e1tica en mujeres sanas en edad reproductiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amelia Valladolid Urdangaray <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Melchor Marcos Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Herruzo nalda <\/li>\n<li> Martinez perez-menda\u00f1a Francisco Javier (vocal)<\/li>\n<li>justino Rodriguez-alarc\u00f3n gomez (vocal)<\/li>\n<li>nieves Luisa Gonz\u00e1lez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amelia Valladolid Urdangaray Una concentraci\u00f3n elevada de homociste\u00edna plasm\u00e1tica es un factor de riesgo paralos defectos del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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