{"id":76204,"date":"2018-03-09T23:21:35","date_gmt":"2018-03-09T23:21:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacio-i-control-del-proces-de-produccio-de-protea%c2%afnes-hetera%c2%b2logues-en-el-llevat-metilotra%c2%b2fic-pichia-pastoris\/"},"modified":"2018-03-09T23:21:35","modified_gmt":"2018-03-09T23:21:35","slug":"monitorizacio-i-control-del-proces-de-produccio-de-protea%c2%afnes-hetera%c2%b2logues-en-el-llevat-metilotra%c2%b2fic-pichia-pastoris","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ingenieria-y-tecnologia-quimicas\/monitorizacio-i-control-del-proces-de-produccio-de-protea%c2%afnes-hetera%c2%b2logues-en-el-llevat-metilotra%c2%b2fic-pichia-pastoris\/","title":{"rendered":"Monitorizaci\u00f3 i control del proc\u00e9s de producci\u00f3 de prote\u00c1\u00afnes heter\u00f3logues en el llevat metilotr\u00f3fic pichia pastoris"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cos Busquets Jos\u00e9 Oriol <\/strong><\/h2>\n<p>Este trabajo se centra en la investigaci\u00f3n de la producci\u00f3n de prote\u00ednas heter\u00f3logas en la levadura metilotr\u00f3fica pichia pastoris. La principal ventaja de la utilizaci\u00f3n de este sistema de expresi\u00f3n es la existencia del promotor alcohol oxidasa, uno de los m\u00e1s eficaces y fuertemente regulados por la presencia de metanol cuando se utiliza como \u00fanica fuente de carbono. el gen hu\u00e9sped utilizado es una lipasas (e.C. 3.1.1.3.) Que pertenece al hongo rhizopus oryzae. Dicha prote\u00edna tiene un gran inter\u00e9s industrial y biotecnol\u00f3gico por sus numerosas y variadas aplicaciones.  de las cuatro cepas diferentes de que se disponen, de diferente fenotipo (mut+ y muts) y cada una de ellas con una o varias copias del gen, se ha seleccionado bajo criterios de productividad y din\u00e1mica de crecimiento, la mas apropiada para una posterior explotaci\u00f3n en cultivo semicontinuo, en este caso muts singlecopy.  uno de los grande problemas que presenta este tipo de cultivo es la reproducibilidad y el control de la concentraci\u00f3n de metanol que no se aconseja superar los niveles establecidos como t\u00f3xicos de 10 g.1-1. El an\u00e1lisis de la composici\u00f3n de gases de salida del fermentador, la extracci\u00f3n de muestra de forma autom\u00e1tica y la gesti\u00f3n en l\u00ednea de toda la informaci\u00f3n generada durante el cultivo en un software espec\u00edfico, mejoran significativamente el seguimiento y el control del sistema. Al disponer de m\u00faltiples medidas en l\u00ednea, es posible estimar variables de estado como la biomasa o la velocidad espec\u00edfica de crecimiento de gran inter\u00e9s para conocer el estado fisiol\u00f3gico del microorganismo.  para mantener la concentraci\u00f3n de metanol estable durante el cultivo se ha propuesto la utilizaci\u00f3n de un lazo de control retroalimentado probando diferentes controladores cl\u00e1sicos basados en el error. Los continuos cambios en la din\u00e1mica del sistema y el tiempo muerto tambi\u00e9n variable provoca que controladores como el \u00abon-off\u00bb y proporcion<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3 i control del proc\u00e9s de producci\u00f3 de prote\u00c1\u00afnes heter\u00f3logues en el llevat metilotr\u00f3fic pichia pastoris<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3 i control del proc\u00e9s de producci\u00f3 de prote\u00c1\u00afnes heter\u00f3logues en el llevat metilotr\u00f3fic pichia pastoris <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cos Busquets Jos\u00e9 Oriol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Valdero Barranco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manel Poch espallargas <\/li>\n<li> Faria c. ferreira eugenio Manuel de (vocal)<\/li>\n<li>Javier Lafuente sancho (vocal)<\/li>\n<li>jordi xavier Feliu gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cos Busquets Jos\u00e9 Oriol Este trabajo se centra en la investigaci\u00f3n de la producci\u00f3n de prote\u00ednas heter\u00f3logas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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