{"id":76223,"date":"2018-03-09T23:21:35","date_gmt":"2018-03-09T23:21:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-mhax1-un-gen-que-se-induce-en-la-activacion-de-macrofagos\/"},"modified":"2018-03-09T23:21:35","modified_gmt":"2018-03-09T23:21:35","slug":"caracterizacion-de-mhax1-un-gen-que-se-induce-en-la-activacion-de-macrofagos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-de-mhax1-un-gen-que-se-induce-en-la-activacion-de-macrofagos\/","title":{"rendered":"Caracterizacion de mhax1, un gen que se induce en la activacion de macrofagos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pupo Balboa Judith Beatriz <\/strong><\/h2>\n<p>La caracterizaci\u00f3n del cdna de mhax-1 permiti\u00f3 concluir que la transcripcion de este gen da lugar a dos mensajeros  como resultado  de un procesamiento de corte y empalme alternativos del transcrito primario. Uno de los mensajeros retiene el  segundo intr\u00f3n, dando lugar al mensajero mayor. El otro mensajero, donde se han eliminado todos los intrones y que contiene todos los exones, se le ha denominado mensajero corto. Ambos se expresan en las c\u00e9lulas raw 264.7 y en leucocitos de rat\u00f3n, y se inducen  en las c\u00e9lulas raw 264.7 por efecto del lps y  la s\u00edlice, agentes estimuladores de la respuesta inflamatoria. El mensajero mayor origina una proteina truncada  como consecuencia de la aparici\u00f3n de un triplete fin de mensaje al incorporarse el intr\u00f3n 2.  Esta proteina es inestable. El mensajero corto codifica una proteina de 35 kda que contiene la pauta completa. Esta proteina est\u00e1 mayoritariamente expresada en todas las c\u00e9lulas ensayadas.  El an\u00e1lisis funcional de ambas proteinas revel\u00f3 que no producen ning\u00fan efecto sobre la apoptosis  inducida por bax. La caracterizaci\u00f3n bioinformatica del gen revel\u00f3 que se localiza en el cromosoma 3 de rat\u00f3n y contiene 7 exones y 6 intrones. Se ha aislado 1,2 kb de la secuencia 5 prima flanqueante del gen y se ha estudiado como regi\u00f3n promotora. Este fragmento de dna es suficiente para que ocurra la transcripci\u00f3n. Su actividad no se induce por efecto del lps y en cambio es inducida por el interfer\u00f3n gamma.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de mhax1, un gen que se induce en la activacion de macrofagos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de mhax1, un gen que se induce en la activacion de macrofagos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pupo Balboa Judith Beatriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Sanchez Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Moreno sanz <\/li>\n<li>Manuel Freire ramos (vocal)<\/li>\n<li>Carlos Martinez campa (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pupo Balboa Judith Beatriz La caracterizaci\u00f3n del cdna de mhax-1 permiti\u00f3 concluir que la transcripcion de este [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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